About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Shoc2tm1.2Mhan
targeted mutation 1.2, Min Han
MGI:4459450
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Shoc2tm1.2Mhan/Shoc2tm1.2Mhan involves: 129S6/SvEvTac * BALB/c * C57BL/6 MGI:4459453
cn2
Shoc2tm1.1Mhan/Shoc2tm1.2Mhan
Tg(Tek-cre)#Xya/0
involves: 129S6/SvEvTac * BALB/c * C57BL/6 * Kunming MGI:4459509


Genotype
MGI:4459453
hm1
Allelic
Composition
Shoc2tm1.2Mhan/Shoc2tm1.2Mhan
Genetic
Background
involves: 129S6/SvEvTac * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shoc2tm1.2Mhan mutation (0 available); any Shoc2 mutation (43 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• embryonic lethality is observed with partial resorption of embryos seen at E8.5




Genotype
MGI:4459509
cn2
Allelic
Composition
Shoc2tm1.1Mhan/Shoc2tm1.2Mhan
Tg(Tek-cre)#Xya/0
Genetic
Background
involves: 129S6/SvEvTac * BALB/c * C57BL/6 * Kunming
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shoc2tm1.1Mhan mutation (0 available); any Shoc2 mutation (43 available)
Shoc2tm1.2Mhan mutation (0 available); any Shoc2 mutation (43 available)
Tg(Tek-cre)#Xya mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• embryos appear viable at E11.5, but from E12.5-14.5 some embryos exhibit hemorrhage and edema; death occurs at or after E13.5

cardiovascular system
N
• mutants and controls show similar vascular patterns at E10.5 and endothelial cells are surrounded by vascular smooth muscle cells, similar to controls, suggesting that blood vessel maturation and integrity during development aren't compromised
• observed at E13.5 and 14.5
• observed in most embryos at E14.5
• endothelial-mesenchymal transition within the atrioventricular canal is abnormal in mutants with AVC endothelial cells displaying less expansion in E9.5 cushion explant cultures and less (about 50%) transformed mesenchymal cells detected compared to controls
• atrioventricular canal mesenchymal cells in explant cultures show significantly reduced proliferation compare to controls at E11.5
• at E11.5, atrioventricular cushion volumes are about 40.8% smaller than controls, but cell density of AV cushions are comparable to controls
• outflow tract cushions do not show significant size difference from controls
• valves are underdeveloped in mutants, with enlarged bulbous primordial leaflets
• outlflow tract valves in all mutants are asymmetrically aligned in contrast to controls
• observed at E13.5 and 14.5
• observed at E13.5 and 14.5
• at E13.5 and 14.5 ventricular septal defects are observed
• some sporadic hemorrhages are observed at E12.5

embryo
N
• placental size and structure is comparable at E13.5 between mutants and controls
• embryos display smaller body size compared to wild-type littermates at E13.5

growth/size/body
• embryos display smaller body size compared to wild-type littermates at E13.5

homeostasis/metabolism
• at E14.5, about half of the embryos exhibit severe dorsal subcutaneous edema

respiratory system
• observed in most embryos at E14.5

integument
• at E14.5, about half of the embryos exhibit severe dorsal subcutaneous edema





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/12/2024
MGI 6.24
The Jackson Laboratory