Phenotypes associated with this allele

• Allele Symbol: Timd4^tm1Wouy
• Allele Name: targeted mutation 1, Wenjun Ouyang
• Allele ID: MGI:4459454
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Timd4^tm1Wouy/Timd4^tm1Wouy	involves: 129	MGI:4459463

Genotype
MGI:4459463

hm1

• Allelic Composition: Timd4^tm1Wouy/Timd4^tm1Wouy
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased leukocyte cell number ( J:160304 )

• mice exhibit an increase in lymphoid and myeloid cells in the peritoneum compared with wild-type mice

increased lymphocyte cell number ( J:160304 )

• in the peritoneum

increased IgG2a level ( J:160304 )

• at 6 months

abnormal macrophage physiology ( J:160304 )

• resident peritoneal macrophages exhibit reduced binding of apoptotic cells compared with wild-type cells

• resident peritoneal macrophages exhibit a slight decrease in Fc receptor-mediated uptake of IgG-coated beads compared with wild-type cells

• fewer necrotic cells associate with macrophages compared with wild-type cells

• unstimulated macrophages exhibit increased TNF-alpha secretion compared with wild-type cells

• LPS fails to stimulate as much TNF-alpha production from peritoneal macrophages compared with similarly treated wild-type cells

• however, association with and internalization of C3-coated sheep red blood cells is normal

impaired macrophage phagocytosis ( J:160304 )

• resident peritoneal macrophages exhibit reduced phagocytosis of apoptotic cells compared with wild-type mice

• however, thioglycollate-activated macrophages exhibit normal phagocytosis of apoptotic cells

decreased tumor necrosis factor secretion ( J:160304 )

• LPS fails to stimulate as much TNF-alpha production from peritoneal macrophages compared with similarly treated wild-type cells

increased tumor necrosis factor secretion ( J:160304 )

• unstimulated resident peritoneal macrophages exhibit increased TNF-alpha secretion compared with wild-type cells

hematopoietic system

increased leukocyte cell number ( J:160304 )

• mice exhibit an increase in lymphoid and myeloid cells in the peritoneum compared with wild-type mice

increased lymphocyte cell number ( J:160304 )

• in the peritoneum

increased IgG2a level ( J:160304 )

• at 6 months

abnormal macrophage physiology ( J:160304 )

• resident peritoneal macrophages exhibit reduced binding of apoptotic cells compared with wild-type cells

• resident peritoneal macrophages exhibit a slight decrease in Fc receptor-mediated uptake of IgG-coated beads compared with wild-type cells

• fewer necrotic cells associate with macrophages compared with wild-type cells

• unstimulated macrophages exhibit increased TNF-alpha secretion compared with wild-type cells

• LPS fails to stimulate as much TNF-alpha production from peritoneal macrophages compared with similarly treated wild-type cells

• however, association with and internalization of C3-coated sheep red blood cells is normal

impaired macrophage phagocytosis ( J:160304 )

• resident peritoneal macrophages exhibit reduced phagocytosis of apoptotic cells compared with wild-type mice

• however, thioglycollate-activated macrophages exhibit normal phagocytosis of apoptotic cells

cellular

impaired macrophage phagocytosis ( J:160304 )

• resident peritoneal macrophages exhibit reduced phagocytosis of apoptotic cells compared with wild-type mice

• however, thioglycollate-activated macrophages exhibit normal phagocytosis of apoptotic cells