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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Il17rctm1Lex
targeted mutation 1, Lexicon Genetics
MGI:4459513
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Il17rctm1Lex/Il17rctm1Lex involves: C57BL/6 MGI:4459524
hm2
Il17rctm1Lex/Il17rctm1Lex Not Specified MGI:4459514


Genotype
MGI:4459524
hm1
Allelic
Composition
Il17rctm1Lex/Il17rctm1Lex
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il17rctm1Lex mutation (4 available); any Il17rc mutation (34 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• The expression of CXCL1, CXCL2, CCL2, and CCL5, but not CCL20, is significantly reduced
• IL17A producing T cells are significantly increased in inguinal lymph nodes and spleens
• a delay in disease onset as well as reduced disease severity in the MOG peptide induced EAE
• decrease in the total number of immune cells infiltrating the brain and spinal cord in response to MOG peptide

homeostasis/metabolism
• The expression of CXCL1, CXCL2, CCL2, and CCL5, but not CCL20, is significantly reduced




Genotype
MGI:4459514
hm2
Allelic
Composition
Il17rctm1Lex/Il17rctm1Lex
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il17rctm1Lex mutation (4 available); any Il17rc mutation (34 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory