All Phenotypes Il17rc<tm1Lex> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Il17rc^tm1Lex
targeted mutation 1, Lexicon Genetics
MGI:4459513

Summary

2 genotypes

Allelic Composition	Il17rc^tm1Lex/Il17rc^tm1Lex
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il17rc^tm1Lex mutation (4 available); any Il17rc mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal chemokine level ( J:159874 )

• The expression of CXCL1, CXCL2, CCL2, and CCL5, but not CCL20, is significantly reduced

• IL17A producing T cells are significantly increased in inguinal lymph nodes and spleens

• a delay in disease onset as well as reduced disease severity in the MOG peptide induced EAE

decreased inflammatory response ( J:159874 )

• decrease in the total number of immune cells infiltrating the brain and spinal cord in response to MOG peptide

homeostasis/metabolism

abnormal chemokine level ( J:159874 )

• The expression of CXCL1, CXCL2, CCL2, and CCL5, but not CCL20, is significantly reduced

Allelic Composition	Il17rc^tm1Lex/Il17rc^tm1Lex
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il17rc^tm1Lex mutation (4 available); any Il17rc mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:161073 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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