All Phenotypes Rnf128<tm1Cdon> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rnf128^tm1Cdon/Rnf128^tm1Cdon	involves: 129 * C57BL/6	MGI:4459538
hm2	Rnf128^tm1Cdon/Rnf128^tm1Cdon	involves: C57BL/6	MGI:4459533
ht3	Rnf128^tm1Cdon/Rnf128⁺	involves: 129 * C57BL/6	MGI:4459537
cx4	Rnf128^tm1Cdon/Rnf128^tm1Cdon Tg(TcraTcrb)425Cbn/0	involves: 129 * BALB/c * C57BL/6	MGI:4459535
cx5	Foxp3^tm2Ayr/Foxp3⁺ Rnf128^tm1Cdon/Rnf128^tm1Cdon	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:4459536

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased splenocyte proliferation ( J:160681 )

• splenocytes from ovalbumin primed mice when restimulated with different concentrations of OVA protein fail to exhibit a reduced immune response

• increased in response to MOG peptide restimulation of immunized mice

enlarged spleen ( J:160681 )

• at 18-20 months of age 27 to 50 percent exhibit splenomegaly

• at 26-28 months of age 27 to 75 percent exhibit splenomegaly

increased IgG1 level ( J:160681 )

• slightly elevated anti-OVA IgG1 levels in intranasal immunized asthma model

increased IgM level ( J:160681 )

• anti-OVA IgM increase in intranasal immunized asthma model

abnormal regulatory T cell physiology ( J:160681 )

• reduced suppression of wild-type naive CD4+ T cells when compared with wild-type Treg cells

enlarged mesenteric lymph nodes ( J:160681 )

• beginning at 18 months in some mice

increased interferon-gamma secretion ( J:160681 )

• splenocytes from ovalbumin primed mice when restimulated with different concentrations of OVA protein fail to exhibit a reduced immune response

• by CD4 T cells and by CD4 T cells activated under Th1 and Th17 cell condition

• by CNS infiltrating CD4 T cells in response to MOG peptide immunization

abnormal interleukin secretion ( J:160681 )

• increased interleukin-22 secretion from T cells of ovalbumin primed mice when they are restimulated with OVA

decreased interleukin-13 secretion ( J:160681 )

• T cells from ovalbumin primed mice when they are restimulated with OVA

increased interleukin-17 secretion ( J:160681 )

• by CD4 T cells and by CD4 T cells activated under Th1 and Th17 cell condition

• by CNS infiltrating CD4 T cells in response to MOG peptide immunization

• by T cells from ovalbumin primed mice when restimulated with OVA

increased interleukin-2 secretion ( J:160681 )

• splenocytes from ovalbumin primed mice when restimulated with different concentrations of OVA protein fail to exhibit a reduced immune response

increased interleukin-21 secretion ( J:160681 )

• in T cells from ovalbumin primed mice when they are restimulated with OVA

decreased interleukin-4 secretion ( J:160681 )

• under Th2 cell polarizing conditions

• in splenocytes that are restimulated with Ova peptide

increased interleukin-4 secretion ( J:160681 )

• splenocytes from ovalbumin primed mice when restimulated with different concentrations of OVA protein fail to exhibit a reduced immune response

decreased interleukin-5 secretion ( J:160681 )

• T cells from ovalbumin primed mice when they are restimulated with OVA

abnormal immune tolerance ( J:160681 )

• abnormal oral tolerance in response to secondary ovalbumin exposure

increased susceptibility to experimental autoimmune encephalomyelitis ( J:160681 )

increased anti-double stranded DNA antibody level ( J:160681 )

• at 18-20 months

CNS inflammation ( J:160681 )

• accumulate more CD4+ T cells in the central nervous system (CNS)

lung inflammation ( J:160681 )

• at 18-20 months mononuclear cell infiltration

hematopoietic system

increased splenocyte proliferation ( J:160681 )

• splenocytes from ovalbumin primed mice when restimulated with different concentrations of OVA protein fail to exhibit a reduced immune response

• increased in response to MOG peptide restimulation of immunized mice

enlarged spleen ( J:160681 )

• at 18-20 months of age 27 to 50 percent exhibit splenomegaly

• at 26-28 months of age 27 to 75 percent exhibit splenomegaly

increased IgG1 level ( J:160681 )

• slightly elevated anti-OVA IgG1 levels in intranasal immunized asthma model

increased IgM level ( J:160681 )

• anti-OVA IgM increase in intranasal immunized asthma model

abnormal regulatory T cell physiology ( J:160681 )

• reduced suppression of wild-type naive CD4+ T cells when compared with wild-type Treg cells

respiratory system

lung inflammation ( J:160681 )

• at 18-20 months mononuclear cell infiltration

nervous system

CNS inflammation ( J:160681 )

• accumulate more CD4+ T cells in the central nervous system (CNS)

cellular

increased splenocyte proliferation ( J:160681 )

• splenocytes from ovalbumin primed mice when restimulated with different concentrations of OVA protein fail to exhibit a reduced immune response

• increased in response to MOG peptide restimulation of immunized mice

growth/size/body

enlarged spleen ( J:160681 )

• at 18-20 months of age 27 to 50 percent exhibit splenomegaly

• at 26-28 months of age 27 to 75 percent exhibit splenomegaly

Allelic Composition	Rnf128^tm1Cdon/Rnf128^tm1Cdon
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rnf128^tm1Cdon mutation (0 available); any Rnf128 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased T cell proliferation ( J:160681 )

• nave CD4 T cells when stimulated with anti-CD3 and anti-CD28 compared to wild-type

increased interferon-gamma secretion ( J:160681 )

• by CD4 T cells and nave CD4 T cells when stimulated with anti-CD3 and anti-CD28 compared to wild-type

increased interleukin-17 secretion ( J:160681 )

• by CD4 T cells

increased interleukin-2 secretion ( J:160681 )

• nave CD4 T cells when stimulated with anti-CD3 and anti-CD28 compared to wild-type

increased anti-double stranded DNA antibody level ( J:160681 )

• at 18-20 months

hematopoietic system

increased T cell proliferation ( J:160681 )

• nave CD4 T cells when stimulated with anti-CD3 and anti-CD28 compared to wild-type

cellular

increased T cell proliferation ( J:160681 )

• nave CD4 T cells when stimulated with anti-CD3 and anti-CD28 compared to wild-type

Allelic Composition	Rnf128^tm1Cdon/Rnf128⁺
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rnf128^tm1Cdon mutation (0 available); any Rnf128 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased susceptibility to experimental autoimmune encephalomyelitis ( J:160681 )

Allelic Composition	Rnf128^tm1Cdon/Rnf128^tm1Cdon Tg(TcraTcrb)425Cbn/0
Genetic Background	involves: 129 * BALB/c * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rnf128^tm1Cdon mutation (0 available); any Rnf128 mutation (10 available)
Tg(TcraTcrb)425Cbn mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

increased splenocyte proliferation ( J:160681 )

• V alpha 2, CD44+ CD4+ T cells from ovalbumin primed mice when stimulated in culture fail to exhibit a reduced immune response

immune system

increased splenocyte proliferation ( J:160681 )

• V alpha 2, CD44+ CD4+ T cells from ovalbumin primed mice when stimulated in culture fail to exhibit a reduced immune response

increased interferon-gamma secretion ( J:160681 )

• V alpha 2, CD44+ CD4+ T cells from ovalbumin primed mice when stimulated in culture fail to exhibit a reduced immune response

increased interleukin-2 secretion ( J:160681 )

• V alpha 2, CD44+ CD4+ T cells from ovalbumin primed mice when stimulated in culture fail to exhibit a reduced immune response

abnormal immune tolerance ( J:160681 )

• abnormal antigen-specific CD4+ T cell tolerance

cellular

increased splenocyte proliferation ( J:160681 )

• V alpha 2, CD44+ CD4+ T cells from ovalbumin primed mice when stimulated in culture fail to exhibit a reduced immune response

Allelic Composition	Foxp3^tm2Ayr/Foxp3⁺ Rnf128^tm1Cdon/Rnf128^tm1Cdon
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp3^tm2Ayr mutation (6 available); any Foxp3 mutation (58 available)
Rnf128^tm1Cdon mutation (0 available); any Rnf128 mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal regulatory T cell physiology ( J:160681 )

• reduced suppression of wild-type naive CD4+ T cells when compared with wild-type Treg cells

• TGFbeta induced Foxp3-expressing Treg, iTreg, cells have a reduced ability to inhibit the proliferation of nave CD4+ T cells

hematopoietic system

abnormal regulatory T cell physiology ( J:160681 )

• reduced suppression of wild-type naive CD4+ T cells when compared with wild-type Treg cells

• TGFbeta induced Foxp3-expressing Treg, iTreg, cells have a reduced ability to inhibit the proliferation of nave CD4+ T cells

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