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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		C1galt1c1tm1.2Rdcu
targeted mutation 1.2, Richard D Cummings
MGI:4459541
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		C1galt1c1tm1.2Rdcu/C1galt1c1+ involves: 129S6/SvEvTac * C57BL/6J * FVB/N MGI:4459547
ot2
 		C1galt1c1tm1.2Rdcu/Y involves: 129S6/SvEvTac * C57BL/6J * FVB/N MGI:4459548


Genotype
MGI:4459547
ht1
Allelic
Composition		 C1galt1c1tm1.2Rdcu/C1galt1c1+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C1galt1c1tm1.2Rdcu mutation (0 available); any C1galt1c1 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:160290 )
• remaining mice die postnatally
embryonic lethality during organogenesis, incomplete penetrance ( J:160290 )
• 7 of 25 mice die between E10.5 and E12.5

cardiovascular system
abnormal blood vessel morphology ( J:160290 )
• 3 of 6 mice that survive to E14.5 exhibit disorganized vascular systems compared with wild-type mice
hemorrhage ( J:160290 )
• between E10.5 and E12.5, 7 of 25 mice exhibit hemorrhaging unlike wild-type mice
• 3 of 6 mice that survive to E14.5 exhibit hemorrhaging unlike wild-type mice

growth/size/body
postnatal growth retardation ( J:160290 )




Genotype
MGI:4459548
ot2
Allelic
Composition		 C1galt1c1tm1.2Rdcu/Y
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C1galt1c1tm1.2Rdcu mutation (0 available); any C1galt1c1 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

cardiovascular system
internal hemorrhage ( J:160290 )
• at E10.5 to E12.5, mice exhibit brain and spinal cord hemorrhages unlike wild-type mice
spinal hemorrhage ( J:160290 )
• at E10.5 to E12.5

embryo
embryonic growth retardation ( J:160290 )
• at E10.5 to E12.5

growth/size/body
embryonic growth retardation ( J:160290 )
• at E10.5 to E12.5

nervous system
spinal hemorrhage ( J:160290 )
• at E10.5 to E12.5




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory