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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Kif26btm1.1Ryn
targeted mutation 1.1, Ryuichi Nishinakamura
MGI:4459557
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Kif26btm1.1Ryn/Kif26btm1.1Ryn involves: C57BL/6 * C57BL/6J * CBA MGI:4459636
cx2
 		Gdnftm1Lmgd/Gdnf+
Kif26btm1.1Ryn/Kif26b+ 		involves: 129 * C57BL/6 * C57BL/6J * CBA MGI:4459954


Genotype
MGI:4459636
hm1
Allelic
Composition		 Kif26btm1.1Ryn/Kif26btm1.1Ryn
Genetic
Background		 involves: C57BL/6 * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kif26btm1.1Ryn mutation (0 available); any Kif26b mutation (81 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

renal/urinary system
abnormal kidney cortex morphology ( J:160285 )
• the mesenchyme in the cortical nephrogenic zone is nearly completely absent compared to in wild-type mice
abnormal kidney development ( J:160285 )
• after E11.0, ureteric bud attraction is impaired and fail to invade and branch into the mesenchyme unlike in wild-type mice
• at E12.5, mesenchyme cells undergo apoptosis unlike in wild-type mice
• at E12.5, 7 of 11 mice fail to exhibit bilateral ureteric attraction with remaining mice exhibiting invasion of ureteric bud on one or both sides
• however, cilia are detected in mesenpheric mesenchyme
small kidney ( J:160285 )
• in 11 of 33 mice
absent kidney ( J:160285 )
• bilateral in 22 of 33 mice
kidney degeneration ( J:160285 )
• kidneys disappear by E14.5
single kidney ( J:160285 )
• in 9 of 33 mice
impaired branching involved in ureteric bud morphogenesis ( J:160285 )
• after E11.0, ureteric bud attraction is impaired and fail to invade and branch into the mesenchyme unlike in wild-type mice




Genotype
MGI:4459954
cx2
Allelic
Composition		 Gdnftm1Lmgd/Gdnf+
Kif26btm1.1Ryn/Kif26b+
Genetic
Background		 involves: 129 * C57BL/6 * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gdnftm1Lmgd mutation (1 available); any Gdnf mutation (19 available)
Kif26btm1.1Ryn mutation (0 available); any Kif26b mutation (81 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
renal hypoplasia ( J:160285 )
• more mice exhibit kidney hypoplasia than in either heterozygous mice
absent kidney ( J:160285 )
• more mice exhibit kidney agenesis than in either heterozygous mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory