All Phenotypes Kif26b<tm1.1Ryn> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kif26b^tm1.1Ryn/Kif26b^tm1.1Ryn	involves: C57BL/6 * C57BL/6J * CBA	MGI:4459636
cx2	Gdnf^tm1Lmgd/Gdnf⁺ Kif26b^tm1.1Ryn/Kif26b⁺	involves: 129 * C57BL/6 * C57BL/6J * CBA	MGI:4459954

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality ( J:160285 )

renal/urinary system

abnormal kidney cortex morphology ( J:160285 )

• the mesenchyme in the cortical nephrogenic zone is nearly completely absent compared to in wild-type mice

abnormal kidney development ( J:160285 )

• after E11.0, ureteric bud attraction is impaired and fail to invade and branch into the mesenchyme unlike in wild-type mice

• at E12.5, mesenchyme cells undergo apoptosis unlike in wild-type mice

• at E12.5, 7 of 11 mice fail to exhibit bilateral ureteric attraction with remaining mice exhibiting invasion of ureteric bud on one or both sides

• however, cilia are detected in mesenpheric mesenchyme

small kidney ( J:160285 )

• in 11 of 33 mice

absent kidney ( J:160285 )

• bilateral in 22 of 33 mice

kidney degeneration ( J:160285 )

• kidneys disappear by E14.5

single kidney ( J:160285 )

• in 9 of 33 mice

impaired branching involved in ureteric bud morphogenesis ( J:160285 )

• after E11.0, ureteric bud attraction is impaired and fail to invade and branch into the mesenchyme unlike in wild-type mice

Allelic Composition	Gdnf^tm1Lmgd/Gdnf⁺ Kif26b^tm1.1Ryn/Kif26b⁺
Genetic Background	involves: 129 * C57BL/6 * C57BL/6J * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gdnf^tm1Lmgd mutation (1 available); any Gdnf mutation (19 available)
Kif26b^tm1.1Ryn mutation (0 available); any Kif26b mutation (81 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

renal hypoplasia ( J:160285 )

• more mice exhibit kidney hypoplasia than in either heterozygous mice

absent kidney ( J:160285 )

• more mice exhibit kidney agenesis than in either heterozygous mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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