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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ehmt2tm1.1Cza
targeted mutation 1.1, Colby Zaph
MGI:4459641
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ehmt2tm1.1Cza/Ehmt2tm1.1Cza
Tg(Cd4-cre)1Cwi/0 		involves: C57BL/6 * DBA/2 * SJL MGI:4459673
cn2
 		Ehmt2tm1.1Cza/Ehmt2tm1.1Cza
Tg(VAV1-cre)1Graf/0 		involves: C57BL/6 * SJL MGI:4459648


Genotype
MGI:4459673
cn1
Allelic
Composition		 Ehmt2tm1.1Cza/Ehmt2tm1.1Cza
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: C57BL/6 * DBA/2 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ehmt2tm1.1Cza mutation (0 available); any Ehmt2 mutation (55 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased IgG1 level ( J:160938 )
• decreased levels of T. muris specific serum IgG1 post-infection
increased IgG2a level ( J:160938 )
• increased levels of T. muris?speciic serum IgG2a post-infection
increased interferon-gamma secretion ( J:160938 )
• in the mesenteric lymph nodes of T. muris infected mice
decreased interleukin-4 secretion ( J:160938 )
• in the mesenteric lymph nodes of T. muris infected mice
increased susceptibility to parasitic infection ( J:160938 )
• susceptible to T. muris infection, failing to clear parasites from the GI tract

hematopoietic system
decreased IgG1 level ( J:160938 )
• decreased levels of T. muris specific serum IgG1 post-infection
increased IgG2a level ( J:160938 )
• increased levels of T. muris?speciic serum IgG2a post-infection




Genotype
MGI:4459648
cn2
Allelic
Composition		 Ehmt2tm1.1Cza/Ehmt2tm1.1Cza
Tg(VAV1-cre)1Graf/0
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ehmt2tm1.1Cza mutation (0 available); any Ehmt2 mutation (55 available)
Tg(VAV1-cre)1Graf mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Goblet cell hyperplasia in response to T. muris infection in Ehmt2tm1.1Cza/Ehmt2tm1.1Cza Tg(VAV1-cre)1Graf/0 mice and treatment with an anti-IFN-gamma antibody fails to recover the hyperplasia

immune system
decreased interleukin-13 secretion ( J:160938 )
• in neutral or Th2 polarizing culture conditions
increased interleukin-17 secretion ( J:160938 )
• under neutral and Th2 conditions increased IL17A
decreased interleukin-4 secretion ( J:160938 )
• in neutral culture conditions
decreased interleukin-5 secretion ( J:160938 )
• in neutral or Th2 polarizing culture conditions
increased susceptibility to parasitic infection ( J:160938 )
• susceptible to T. muris infection, failing to clear parasites from the GI tract

digestive/alimentary system
abnormal intestinal goblet cell morphology ( J:160938 )
• hyperplasia in response to T. muris infection

cellular
abnormal intestinal goblet cell morphology ( J:160938 )
• hyperplasia in response to T. muris infection




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/03/2024
MGI 6.24 		The Jackson Laboratory