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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fgfr3tm6.1Cxd
targeted mutation 6.1, Chu-Xia Deng
MGI:4459833
Summary 4 genotypes


Genotype
MGI:6116891
cn1
Allelic
Composition		 Fgfr2tm1Dor/Fgfr2tm1Dor
Fgfr3tm6.1Cxd/Fgfr3tm6.1Cxd
Foxg1tm1(cre)Skm/Foxg1+
Fgfr1tm1Jpa/Fgfr1tm1Jpa
Frs3tm1Jheb/Frs3tm1Jheb
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1tm1Jpa mutation (0 available); any Fgfr1 mutation (223 available)
Fgfr2tm1Dor mutation (3 available); any Fgfr2 mutation (90 available)
Fgfr3tm6.1Cxd mutation (0 available); any Fgfr3 mutation (54 available)
Foxg1tm1(cre)Skm mutation (2 available); any Foxg1 mutation (29 available)
Frs3tm1Jheb mutation (0 available); any Frs3 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system




Genotype
MGI:6116892
cn2
Allelic
Composition		 Fgfr2tm1Dor/Fgfr2+
Fgfr3tm6.1Cxd/Fgfr3tm6.1Cxd
Foxg1tm1(cre)Skm/Foxg1+
Fgfr1tm1Jpa/Fgfr1tm1Jpa
Frs3tm1Jheb/Frs3tm1Jheb
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1tm1Jpa mutation (0 available); any Fgfr1 mutation (223 available)
Fgfr2tm1Dor mutation (3 available); any Fgfr2 mutation (90 available)
Fgfr3tm6.1Cxd mutation (0 available); any Fgfr3 mutation (54 available)
Foxg1tm1(cre)Skm mutation (2 available); any Foxg1 mutation (29 available)
Frs3tm1Jheb mutation (0 available); any Frs3 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
cellular phenotype ( J:242687 )
N
• cell survival and cell division at E8.75 according to mitotic marker p-HH3 immunoreactivity

nervous system
nervous system phenotype ( J:242687 )
N
• brain morphology at E12.5




Genotype
MGI:6116893
cn3
Allelic
Composition		 Fgfr2tm1Dor/Fgfr2tm1Dor
Fgfr3tm6.1Cxd/Fgfr3tm6.1Cxd
Foxg1tm1(cre)Skm/Foxg1+
Fgfr1tm3.1Sor/Fgfr1tm1Jpa
Frs3tm1Jheb/Frs3tm1Jheb
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1tm1Jpa mutation (0 available); any Fgfr1 mutation (223 available)
Fgfr1tm3.1Sor mutation (0 available); any Fgfr1 mutation (223 available)
Fgfr2tm1Dor mutation (3 available); any Fgfr2 mutation (90 available)
Fgfr3tm6.1Cxd mutation (0 available); any Fgfr3 mutation (54 available)
Foxg1tm1(cre)Skm mutation (2 available); any Foxg1 mutation (29 available)
Frs3tm1Jheb mutation (0 available); any Frs3 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
cellular phenotype ( J:242687 )
N
• cell division at E8.75 according to mitotic marker p-HH3 immunoreactivity
increased cell death ( J:242687 )
• according to TUNEL assay at E8.75

nervous system




Genotype
MGI:6116894
cn4
Allelic
Composition		 Fgfr2tm1Dor/Fgfr2tm1Dor
Fgfr3tm6.1Cxd/Fgfr3tm6.1Cxd
Foxg1tm1(cre)Skm/Foxg1+
Fgfr1tm6.1Jrt/Fgfr1tm1Jpa
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr1tm1Jpa mutation (0 available); any Fgfr1 mutation (223 available)
Fgfr1tm6.1Jrt mutation (0 available); any Fgfr1 mutation (223 available)
Fgfr2tm1Dor mutation (3 available); any Fgfr2 mutation (90 available)
Fgfr3tm6.1Cxd mutation (0 available); any Fgfr3 mutation (54 available)
Foxg1tm1(cre)Skm mutation (2 available); any Foxg1 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:242687 )
N
• brain morphology at E12.5




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory