Phenotypes associated with this allele

• Allele Symbol: Gimap1^tm1.1Gwb
• Allele Name: targeted mutation 1.1, Geoffrey W Butcher
• Allele ID: MGI:4459837
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gimap1^tm1.1Gwb/Gimap1^tm1.1Gwb Tg(CD2-icre)4Kio/0	involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca	MGI:4459839

Genotype
MGI:4459839

cn1

• Allelic Composition: Gimap1^tm1.1Gwb/Gimap1^tm1.1Gwb; Tg(CD2-icre)4Kio/0
• Genetic Background: involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased lymphocyte cell number ( J:160782 )

• the overall spleenic cellularity is reduced by approximately 40%

• the lymph node cellualrity is severely reduced

decreased B cell number ( J:160782 )

• in lymph nodes

decreased transitional stage T2 B cell number ( J:160782 )

decreased B-1a cell number ( J:160782 )

• in peritoneum

decreased B-1b cell number ( J:160782 )

• in peritoneum

decreased B-2 B cell number ( J:160782 )

• in peritoneum

decreased follicular B cell number ( J:160782 )

decreased marginal zone B cell number ( J:160782 )

decreased T cell number ( J:160782 )

• in peritoneum and blood

decreased thymocyte number ( J:160782 )

decreased CD4-positive, alpha-beta T cell number ( J:160782 )

• in spleen and lymph node and the CD4 single positive subset in the thymus

decreased CD8-positive, alpha-beta T cell number ( J:160782 )

• in spleen and lymph node and the CD8 single positive subset in the thymus

abnormal CD4-positive, alpha-beta T cell physiology ( J:160782 )

• decreased thymocyte survival in culture

abnormal CD8-positive, alpha-beta T cell physiology ( J:160782 )

• a trend towards decreased thymocyte survival in culture

immune system

decreased lymphocyte cell number ( J:160782 )

• the overall spleenic cellularity is reduced by approximately 40%

• the lymph node cellualrity is severely reduced

decreased B cell number ( J:160782 )

• in lymph nodes

decreased transitional stage T2 B cell number ( J:160782 )

decreased B-1a cell number ( J:160782 )

• in peritoneum

decreased B-1b cell number ( J:160782 )

• in peritoneum

decreased B-2 B cell number ( J:160782 )

• in peritoneum

decreased follicular B cell number ( J:160782 )

decreased marginal zone B cell number ( J:160782 )

decreased T cell number ( J:160782 )

• in peritoneum and blood

decreased thymocyte number ( J:160782 )

decreased CD4-positive, alpha-beta T cell number ( J:160782 )

• in spleen and lymph node and the CD4 single positive subset in the thymus

decreased CD8-positive, alpha-beta T cell number ( J:160782 )

• in spleen and lymph node and the CD8 single positive subset in the thymus

abnormal CD4-positive, alpha-beta T cell physiology ( J:160782 )

• decreased thymocyte survival in culture

abnormal CD8-positive, alpha-beta T cell physiology ( J:160782 )

• a trend towards decreased thymocyte survival in culture

endocrine/exocrine glands

decreased thymocyte number ( J:160782 )