All Phenotypes Avil<tm2(cre)Fawa> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Avil^tm2(cre)Fawa
targeted mutation 2, Fan Wang
MGI:4459942

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Avil^tm2(cre)Fawa/Avil^tm2(cre)Fawa	B6J.129P2-Avil^tm2(cre)Fawa	MGI:6201442
cn2	Avil^tm2(cre)Fawa/Avil⁺ Pik3c3^tm1Fawa/Pik3c3^tm1Fawa	involves: 129P2/OlaHsd	MGI:4460013
cn3	Ano1^tm1.1Jwo/Ano1^tm1.1Jwo Avil^tm2(cre)Fawa/Avil⁺	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:5461903
cn4	Gm34583^tm1.1Bcgen/Gm34583^tm1.1Bcgen Avil^tm2(cre)Fawa/Avil⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:7334895
cn5	Ntrk2^tm4.1Ddg/Ntrk2^tm4.1Ddg Avil^tm2(cre)Fawa/Avil⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:5617021
cn6	Atg7^tm1Tchi/Atg7^tm1Tchi Avil^tm2(cre)Fawa/Avil⁺	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:4460014
cn7	Avil^tm2(cre)Fawa/Avil⁺ Prdm12^tm1.1Ejbd/Prdm12^tm1.1Ejbd	involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N	MGI:6387033

Allelic Composition	Avil^tm2(cre)Fawa/Avil^tm2(cre)Fawa
Genetic Background	B6J.129P2-Avil^tm2(cre)Fawa

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Avil^tm2(cre)Fawa mutation (2 available); any Avil mutation (47 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal mechanical nociception ( J:265529 )

• in a nerve lesion model induced by chronic constriction injury of the left sciatic nerve, mutants do not show reduced mechanical allodynia after decompression as is seen in wild-type mice

allodynia ( J:265529 )

• mice treated with oxaliplatin to induce cold allodynia exhibit more severe cold allodynia in the recovery phase of treatment than wild-type mice

decreased thermal nociceptive threshold ( J:265529 )

• mice exhibit aggravated EAE-induced nociceptive behaviors than control mice, with mice being hypersensitive to nonnociceptive cold stimulus at 15 degrees C, including shortening the latency to the first nocifensive behavior and increased nocifensive events

cellular

abnormal axon extension ( J:265529 )

• axon outgrowth of dorsal root ganglion neurons is often in a single direction and followed by few dynamic growth cones indicating that pathfinding of axon outgrowth is affected

• the velocities of axon extension and retraction are slower in dorsal root ganglia neurons

immune system

increased susceptibility to experimental autoimmune encephalomyelitis ( J:265529 )

• mice exhibit abnormal EAE-induced neural plasticity mainly in IB4+ central projections, with partially disrupted IB4+ dorsal horn layers in the mediolateral extent of lamina II and increased CGRP- and IB4-labeled overlapping region

nervous system

abnormal axon extension ( J:265529 )

• axon outgrowth of dorsal root ganglion neurons is often in a single direction and followed by few dynamic growth cones indicating that pathfinding of axon outgrowth is affected

• the velocities of axon extension and retraction are slower in dorsal root ganglia neurons

abnormal neurite morphology ( J:265529 )

• dorsal root ganglion neurons show reduced neurite length and neurite branching

• axon regeneration is affected in IB4+ but not CGRP+ neurons, with postponed or halted neurite outgrowth of IB4+ dorsal root ganglia neurons

abnormal dorsal root ganglion morphology ( J:265529 )

• dorsal root ganglion neurons show reduced neurite length and neurite branching

• accumulation of myosin IIa in lamellipodia of growth cones of cultured dorsal root ganglia neurons is lower

Allelic Composition	Avil^tm2(cre)Fawa/Avil⁺ Pik3c3^tm1Fawa/Pik3c3^tm1Fawa
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Avil^tm2(cre)Fawa mutation (2 available); any Avil mutation (47 available)
Pik3c3^tm1Fawa mutation (0 available); any Pik3c3 mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:160568 )

• all mice die within 2 weeks of age

nervous system

increased neuron apoptosis ( J:160568 )

• at P5 and P9

abnormal sensory neuron morphology ( J:160568 )

• at P9, sensory neurons exhibit an increase in lysosome-like organelles unlike wild-type cells

• sensory neurons contain numerous large vacuoles unlike wild-type cells

decreased sensory neuron number ( J:160568 )

• at P5, 27% of sensory neurons are lost compared to in wild-type mice

• at P5 and P6, the numbers of TrkB+ and TrkC+ neurons are reduced compared to in wild-type mice

• at P9, only 44% of sensory neurons remain compared to in wild-type mice

• at P9, the numbers of TrkB+ and TrkC+ neurons are reduced compared to in wild-type mice

• at P9, the number of cRet+ neurons is moderately reduced compared to in wild-type mice

• during the early postnatal period, large-diameter mechanosensory and proprioceptive sensory neurons are lost unlike in wild-type mice

abnormal proprioceptive neuron morphology ( J:160568 )

• during the early postnatal period, large-diameter mechanosensory and proprioceptive sensory neurons are lost unlike in wild-type mice

neurodegeneration ( J:160568 )

• at P5, mice exhibit rapid degeneration of mature sensory neuron unlike wild-type mice

• during the early postnatal period, large-diameter mechanosensory and proprioceptive sensory neurons are lost unlike in wild-type mice

axon degeneration ( J:160568 )

• at P9, proprioceptive sensory axon projections to the ventral spinal cord are almost completely degenerated unlike in wild-type mice

• touch sensory innervations of layers III/IV are reduced compared to in wild-type mice

• large diameter myelinated axons exhibit degeneration unlike in wild-type mice

• however, small diameter unmyelinated axons are intact

behavior/neurological

impaired coordination ( J:160568 )

• at P5 to P6

abnormal posture ( J:160568 )

• at P5 to P6, mice exhibit difficulty in maintaining body posture unlike wild-type mice

hindlimb paralysis ( J:160568 )

• at P5 to P6, mice begin to drag their hindlimbs unlike wild-type mice

cellular

increased neuron apoptosis ( J:160568 )

• at P5 and P9

Allelic Composition	Ano1^tm1.1Jwo/Ano1^tm1.1Jwo Avil^tm2(cre)Fawa/Avil⁺
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ano1^tm1.1Jwo mutation (0 available); any Ano1 mutation (60 available)
Avil^tm2(cre)Fawa mutation (2 available); any Avil mutation (47 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:191353 )

N	• mice exhibit normal balance, motor coordination, locomotion and mechanical sensitivities

increased thermal nociceptive threshold ( J:191353 )

• in response to tail immersion in hot water or radiant heat

nervous system

abnormal sensory neuron morphology ( J:191353 )

• dorsal root ganglion sensory neurons exhibit reduced heat-evoked inward chloride current compared with control neurons

integument

integument phenotype ( J:191353 )

N	• mice exhibit normal mechanical sensitivities

Allelic Composition	Gm34583^tm1.1Bcgen/Gm34583^tm1.1Bcgen Avil^tm2(cre)Fawa/Avil⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Avil^tm2(cre)Fawa mutation (2 available); any Avil mutation (47 available)
Gm34583^tm1.1Bcgen mutation (0 available); any Gm34583 mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

hypoalgesia ( J:326871 )

• following L4 spinal nerve ligation-induced, mice exhibit mitigated nerve injury-induced mechanical, heat, and cold nociceptive hypersensitivities with reduced paw withdrawal percentage compared with control mice

homeostasis/metabolism

decreased susceptibility to injury ( J:326871 )

Allelic Composition	Ntrk2^tm4.1Ddg/Ntrk2^tm4.1Ddg Avil^tm2(cre)Fawa/Avil⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Avil^tm2(cre)Fawa mutation (2 available); any Avil mutation (47 available)
Ntrk2^tm4.1Ddg mutation (0 available); any Ntrk2 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal mammary gland sensory innervation pattern ( J:192549 )

• at E13, female mice exhibit reduced sensory neurons innervation of the mammary gland rudiments compared with wild-type mice

endocrine/exocrine glands

abnormal mammary gland sensory innervation pattern ( J:192549 )

• at E13, female mice exhibit reduced sensory neurons innervation of the mammary gland rudiments compared with wild-type mice

integument

abnormal mammary gland sensory innervation pattern ( J:192549 )

• at E13, female mice exhibit reduced sensory neurons innervation of the mammary gland rudiments compared with wild-type mice

Allelic Composition	Atg7^tm1Tchi/Atg7^tm1Tchi Avil^tm2(cre)Fawa/Avil⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atg7^tm1Tchi mutation (3 available); any Atg7 mutation (51 available)
Avil^tm2(cre)Fawa mutation (2 available); any Avil mutation (47 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

increased neuron apoptosis ( J:160568 )

• at 9 months in the dorsal root ganglia

gliosis ( J:160568 )

• at 9 months

abnormal sensory neuron morphology ( J:160568 )

• at 9 months, neurons contain large inclusion bodies and numerous electron-dense organelles unlike in wild-type mice

neurodegeneration ( J:160568 )

• at 9 months, mice exhibit neurodegeneration of TrkA+, cRet+, TrkB+, and TrkC+ sensory neurons unlike in wild-type mice

behavior/neurological

limb grasping ( J:160568 )

• at 7 months

tremors ( J:160568 )

• between 7 and 9 months

bradykinesia ( J:160568 )

• at 7 months, mice exhibit reduced mobility compared with wild-type mice

• between 7 and 9 months, mice exhibit difficulties in movement unlike wild-type mice

limbs/digits/tail

curly tail ( J:160568 )

• between 7 and 9 months, mice develop stiffly twisted tails unlike wild-type mice

cellular

increased neuron apoptosis ( J:160568 )

• at 9 months in the dorsal root ganglia

Allelic Composition	Avil^tm2(cre)Fawa/Avil⁺ Prdm12^tm1.1Ejbd/Prdm12^tm1.1Ejbd
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Avil^tm2(cre)Fawa mutation (2 available); any Avil mutation (47 available)
Prdm12^tm1.1Ejbd mutation (0 available); any Prdm12 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

increased neuron apoptosis ( J:283226 )

• at E16.5 in the dorsal root ganglia

decreased sensory neuron number ( J:283226 )

• reduced neurons expressing nociception markers in the dorsal root ganglia at E15.5 and E18.5

• strongly reduced peptidergic and non-peptidergic projections in the dorsal horn

• reduced Islet1+ neurons in the dorsal root ganglia at E16.5

abnormal superior glossopharyngeal ganglion morphology ( J:283226 )

• reduced superior jugular ganglia at E14.5

small trigeminal ganglion ( J:283226 )

• at E14.5

cellular

increased neuron apoptosis ( J:283226 )

• at E16.5 in the dorsal root ganglia

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