Phenotypes associated with this allele

• Allele Symbol: Bmp2^{tm1(KOMP)Vlcg}
• Allele Name: targeted mutation 1, Velocigene
• Allele ID: MGI:4460567
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bmp2^tm1(KOMP)Vlcg/Bmp2^tm1(KOMP)Vlcg	involves: C57BL/6NTac	MGI:6220872
ht2	Bmp2^tm1(KOMP)Vlcg/Bmp2^+	involves: C57BL/6NTac	MGI:5912401

Genotype
MGI:6220872

hm1

• Allelic Composition: Bmp2^{tm1(KOMP)Vlcg}/Bmp2^{tm1(KOMP)Vlcg}
• Genetic Background: involves: C57BL/6NTac
• Cell Lines: 12406A-H3

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality prior to tooth bud stage ( J:258535 )

• mice die before E12.5

Genotype
MGI:5912401

ht2

• Allelic Composition: Bmp2^{tm1(KOMP)Vlcg}/Bmp2⁺
• Genetic Background: involves: C57BL/6NTac
• Cell Lines: 12406A-H3

growth/size/body

decreased body length ( J:258535 )

• body is shorter

• however, no differences in femur or tibia length are seen

skeleton

decreased rib number ( J:258535 )

• 10 of 13 mice have 12 pairs of ribs and are missing the 13th rib pair at the thoracic vertebra 13

• 3 of 13 mice have 12.5 pairs of ribs and are missing one rib unilaterally

decreased bone mineral content ( J:258535 )

• decrease in bone mineral content

• however, femoral bones do not show differences in maximum load, yield load, work to failure, or stiffness

decreased bone volume ( J:258535 )