Phenotypes associated with this allele

• Allele Symbol: C1qtnf5^{tm1(KOMP)Vlcg}
• Allele Name: targeted mutation 1, Velocigene
• Allele ID: MGI:4460570
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	C1qtnf5^tm1(KOMP)Vlcg/C1qtnf5^tm1(KOMP)Vlcg	involves: C57BL/6NTac	MGI:5823418

Genotype
MGI:5823418

hm1

• Allelic Composition: C1qtnf5^{tm1(KOMP)Vlcg}/C1qtnf5^{tm1(KOMP)Vlcg}
• Genetic Background: involves: C57BL/6NTac
• Cell Lines: 12534A-H11

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:237401 )

N • on a chow diet, mice show no differences in glucose or insulin tolerance relative to wild-type controls

N • HFD-fed mice show normal rates of oxygen consumption, carbon dioxide production, respiratory exchange ratios, and energy expenditure relative to similarly fed wild-type controls

increased insulin secretion ( J:237401 )

• HFD-fed mice show robust insulin secretion at 30 min after glucose injection

• however, no differences are observed in a glucose tolerance test on a HFD

decreased fasting circulating glucose level ( J:237401 )

• aged mice (>10 months of age) fed a HFD later in life show lowered fasting blood glucose levels relative to similarly treated wild-type controls

• however, mice fed a chow diet or HFD at weaning exhibit normal fasting blood glucose levels relative to similarly fed wild-type controls

decreased circulating insulin level ( J:237401 )

• on a chow diet or HFD, mice show significantly lower fasting insulin levels relative to similarly fed wild-type controls

• aged mice (>10 months of age) fed a HFD later in life show lowered fasting insulin levels relative to similarly treated wild-type controls

impaired gluconeogenesis ( J:237401 )

• HFD-fed mice exhibit reduced gluconeogenic gene (glucose-6-phosphatase, G6pc) expression in liver

improved glucose tolerance ( J:237401 )

• aged mice (>10 months of age) fed a HFD later in life show improved glucose tolerance relative to similarly treated wild-type controls

increased insulin sensitivity ( J:237401 )

• on a chow diet or HFD, mice show a significantly lower insulin resistance index (HOMA-IR) relative to similarly fed wild-type controls

• HFD-fed mice show a significantly greater rate of insulin-stimulated glucose clearance in peripheral tissues than similarly fed wild-type controls

• aged mice (>10 months of age) fed a HFD later in life show reduced insulin resistance and improved insulin tolerance relative to similarly treated wild-type controls

decreased liver triglyceride level ( J:237401 )

• HFD-fed mice exhibit reduced hepatic triglyceride content, but not cholesterol levels, relative to similarly fed wild-type controls

• aged mice (>10 months of age) fed a HFD later in life show decreased expression of genes involved in hepatic triglyceride synthesis relative to similarly treated wild-type controls

• however, triglyceride levels in serum and skeletal muscle are normal

liver/biliary system

decreased liver triglyceride level ( J:237401 )

• HFD-fed mice exhibit reduced hepatic triglyceride content, but not cholesterol levels, relative to similarly fed wild-type controls

• aged mice (>10 months of age) fed a HFD later in life show decreased expression of genes involved in hepatic triglyceride synthesis relative to similarly treated wild-type controls

• however, triglyceride levels in serum and skeletal muscle are normal

decreased susceptibility to diet-induced hepatic steatosis ( J:237401 )

• HFD-fed mice exhibit reduced hepatic steatosis relative to similarly fed wild-type controls

behavior/neurological

decreased food intake ( J:237401 )

• HFD-fed mice exhibit a very modest reduction in food intake during the dark cycle relative to similarly fed wild-type controls

• however, no significant changes in average body weight or adiposity are observed over time

endocrine/exocrine glands

increased insulin secretion ( J:237401 )

• HFD-fed mice show robust insulin secretion at 30 min after glucose injection

• however, no differences are observed in a glucose tolerance test on a HFD

growth/size/body

growth/size/body region phenotype ( J:237401 )

N • mice fed a chow diet or a high-fat diet (HFD) exhibit normal body weight and body composition (fat and lean mass) relative to similarly fed wild-type controls

adipose tissue

adipose tissue phenotype ( J:237401 )

N • HFD-fed mice exhibit no alterations in adipose tissue inflammation and fibrosis relative to similarly fed wild-type controls