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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(LRRK2*G2019S)1Mjfa
transgene insertion 1, Matthew Farrer
MGI:4460658
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(LRRK2*G2019S)1Mjfa/Tg(LRRK2*G2019S)1Mjfa involves: FVB/NTac MGI:4460699
tg2
Tg(LRRK2*G2019S)1Mjfa/0 FVB-Tg(LRRK2*G2019S)1Mjfa MGI:5008468


Genotype
MGI:4460699
tg1
Allelic
Composition
Tg(LRRK2*G2019S)1Mjfa/Tg(LRRK2*G2019S)1Mjfa
Genetic
Background
involves: FVB/NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(LRRK2*G2019S)1Mjfa mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• mice are viable

behavior/neurological
N
• mice exhibit normal gross behavior

growth/size/body
N
• mice are normal in size




Genotype
MGI:5008468
tg2
Allelic
Composition
Tg(LRRK2*G2019S)1Mjfa/0
Genetic
Background
FVB-Tg(LRRK2*G2019S)1Mjfa
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(LRRK2*G2019S)1Mjfa mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• primary neurons exhibit reduced neuron outgrowth and branching compared with control neurons
• however, indolocarbazole-treatment partially rescues outgrowth
• primary neurons exhibit reduced neuron outgrowth and branching compared with control neurons
• however, indolocarbazole-treatment partially rescues outgrowth

cellular
• primary neurons exhibit reduced neuron outgrowth and branching compared with control neurons
• however, indolocarbazole-treatment partially rescues outgrowth





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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory