About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Srpk2tm1Nik
targeted mutation 1, Nigel Killeen
MGI:4460670
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Lrrc17tm1Nik/Lrrc17+
Nf1tm1Par/Nf1tm1Par
Srpk2tm1Nik/Srpk2+
Tg(Mx1-cre)1Cgn/0 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA MGI:4460776
cn2
 		Krastm4Tyj/Kras+
Lrrc17tm1Nik/Lrrc17+
Srpk2tm1Nik/Srpk2+
Tg(Mx1-cre)1Cgn/0 		involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA MGI:4460775
cn3
 		Lrrc17tm1Nik/Lrrc17+
Srpk2tm1Nik/Srpk2+
Tg(Mx1-cre)1Cgn/0 		involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA MGI:4460774
cx4
 		Lrrc17tm1Nik/Lrrc17tm1Nik
Srpk2tm1Nik/Srpk2tm1Nik 		involves: 129P2/OlaHsd * C57BL/6 MGI:4460773


Genotype
MGI:4460776
cn1
Allelic
Composition		 Lrrc17tm1Nik/Lrrc17+
Nf1tm1Par/Nf1tm1Par
Srpk2tm1Nik/Srpk2+
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrrc17tm1Nik mutation (0 available); any Lrrc17 mutation (21 available)
Nf1tm1Par mutation (4 available); any Nf1 mutation (161 available)
Srpk2tm1Nik mutation (0 available); any Srpk2 mutation (47 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:161558 )
• in pIpC-treated mice with the same timing as in pIpC-treated Nf1tm1Par/Nf1tm1Par Tg(Mx1-cre)1Cgn mice

immune system
increased leukocyte cell number ( J:161558 )
• pIpC-treated mice develop myeloproliferative disorder with anemia unlike wild-type mice that is similar to in pIpC-treated Nf1tm1Par/Nf1tm1Par Tg(Mx1-cre)1Cgn mice

hematopoietic system
increased leukocyte cell number ( J:161558 )
• pIpC-treated mice develop myeloproliferative disorder with anemia unlike wild-type mice that is similar to in pIpC-treated Nf1tm1Par/Nf1tm1Par Tg(Mx1-cre)1Cgn mice




Genotype
MGI:4460775
cn2
Allelic
Composition		 Krastm4Tyj/Kras+
Lrrc17tm1Nik/Lrrc17+
Srpk2tm1Nik/Srpk2+
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (9 available); any Kras mutation (84 available)
Lrrc17tm1Nik mutation (0 available); any Lrrc17 mutation (21 available)
Srpk2tm1Nik mutation (0 available); any Srpk2 mutation (47 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:161558 )
• in pIpC-treated mice similar to in pIpC-treated Krastm4Tyj Tg(Mx1-cre)1Cgn mice

immune system
increased leukocyte cell number ( J:161558 )
• pIpC-treated mice develop myeloproliferative disorder with anemia unlike wild-type mice that is similar to in pIpC-treated Krastm4Tyj Tg(Mx1-cre)1Cgn mice

hematopoietic system
abnormal blood cell morphology/development ( J:161558 )
• bone marrow cells from pIpC-treated mice spontaneous form colony forming units-granulocyte and macrophage (CFU-GM) in the absence of cytokines unlike wild-type cells
anemia ( J:161558 )
• in pIpC-treated mice similar to in pIpC-treated Krastm4Tyj Tg(Mx1-cre)1Cgn mice
increased leukocyte cell number ( J:161558 )
• pIpC-treated mice develop myeloproliferative disorder with anemia unlike wild-type mice that is similar to in pIpC-treated Krastm4Tyj Tg(Mx1-cre)1Cgn mice




Genotype
MGI:4460774
cn3
Allelic
Composition		 Lrrc17tm1Nik/Lrrc17+
Srpk2tm1Nik/Srpk2+
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrrc17tm1Nik mutation (0 available); any Lrrc17 mutation (21 available)
Srpk2tm1Nik mutation (0 available); any Srpk2 mutation (47 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:161558 )
N
• mice exhibit a normal lifespan and causes of death

neoplasm
neoplasm ( J:161558 )
N
• MOL4070LTR-induced leukemia is the same as in similarly treated wild-type mice

hematopoietic system
hematopoietic system phenotype ( J:161558 )
N
• mice exhibit normal blood counts




Genotype
MGI:4460773
cx4
Allelic
Composition		 Lrrc17tm1Nik/Lrrc17tm1Nik
Srpk2tm1Nik/Srpk2tm1Nik
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrrc17tm1Nik mutation (0 available); any Lrrc17 mutation (21 available)
Srpk2tm1Nik mutation (0 available); any Srpk2 mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:161558 )
• mice are normal and fertile




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory