Phenotypes associated with this allele

• Allele Symbol: Slc4a8^tm1.1Doel
• Allele Name: targeted mutation 1.1, Dominique Eladari
• Allele ID: MGI:4460780
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc4a8^tm1.1Doel/Slc4a8^tm1.1Doel	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:4460804

Genotype
MGI:4460804

hm1

• Allelic Composition: Slc4a8^tm1.1Doel/Slc4a8^tm1.1Doel
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

abnormal kidney physiology ( J:161474 )

• when mice are fed a normal sodium diet, cortical collecting ducts fail to exhibit a sodium ion-dependent intracellular pH change unlike similarly treated wild-type mice

• in amiloride-treated mice, cortical collecting ducts exhibit negative sodium and chloride ion transepithalial fluxes unlike ducts from similarly treated wild-type mice

homeostasis/metabolism

abnormal physiological response to xenobiotic ( J:161474 )

• in amiloride-treated mice, cortical collecting ducts exhibit negative sodium and chloride ion transepithalial fluxes unlike ducts from similarly treated wild-type mice