Phenotypes associated with this allele

• Allele Symbol: Dnmt3b^tm1.1Ics
• Allele Name: targeted mutation 1.1, Mouse Clinical Institute
• Allele ID: MGI:4460909
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Dnmt3b^tm1.1Ics/Dnmt3b^tm2.1Ics	involves: 129S2/SvPas * C57BL/6J	MGI:4460915

Genotype
MGI:4460915

ht1

• Allelic Composition: Dnmt3b^tm1.1Ics/Dnmt3b^tm2.1Ics
• Genetic Background: involves: 129S2/SvPas * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:160567 )

• most mice die within 48 hours after birth and few mice survived to adulthood

skeleton

abnormal skeleton morphology ( J:160567 )

• at 5 months

abnormal cranium morphology ( J:160567 )

• at 5 months, the distance between the coronal suture on the frontal bone and a larger interparietal bone is larger than in wild-type mice

enlarged frontal bone ( J:160567 )

enlarged interparietal bone ( J:160567 )

thoracic vertebral transformation ( J:160567 )

• T13 is transformed into a lumbar vertebra L1 unlike in wild-type mice

lumbar vertebral transformation ( J:160567 )

• L6 is transformed into the sacral vertebra S1

cellular

abnormal DNA methylation ( J:160567 )

• mice exhibit hypomethylation of centromeric minor satellite repeats compared with wild-type mice

growth/size/body

short snout ( J:160567 )

decreased body size ( J:160567 )

craniofacial

abnormal cranium morphology ( J:160567 )

• at 5 months, the distance between the coronal suture on the frontal bone and a larger interparietal bone is larger than in wild-type mice

enlarged frontal bone ( J:160567 )

enlarged interparietal bone ( J:160567 )

short snout ( J:160567 )