Phenotypes associated with this allele

• Allele Symbol: Lrrk2^tm3.1Shn
• Allele Name: targeted mutation 3.1, Jie Shen
• Allele ID: MGI:4460961
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lrrk2^tm3.1Shn/Lrrk2^tm3.1Shn	involves: 129 * C57BL/6	MGI:4460975

Genotype
MGI:4460975

hm1

• Allelic Composition: Lrrk2^tm3.1Shn/Lrrk2^tm3.1Shn
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

abnormal kidney morphology ( J:160542 )

• at 20 months, kidneys appear rough and granular, are smaller, weigh less, and are darker than in wild-type mice

• however, kidneys are normal at 10 weeks

small kidney ( J:160542 )

• at 20 months

decreased kidney weight ( J:160542 )

• at 20 months

kidney atrophy ( J:160542 )

• in aged mice

granular kidney ( J:160542 )

• at 20 months

nervous system

nervous system phenotype ( J:160542 )

N • mice exhibit normal dopaminergic neurons and dopamine turnover