Phenotypes associated with this allele

• Allele Symbol: Ferd3l^tm1Yono
• Allele Name: targeted mutation 1, Yuichi Ono
• Allele ID: MGI:4460989
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ferd3l^tm1Yono/Ferd3l^tm1Yono	involves: C57BL/6	MGI:4460997

Genotype
MGI:4460997

hm1

• Allelic Composition: Ferd3l^tm1Yono/Ferd3l^tm1Yono
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal neuron differentiation ( J:160534 )

• mice exhibit impaired neurogenesis in mesencephalic floor plate cells compared with wild-type mice

• however, mesencephalic dopaminergic neuron patterning, specification, and survival are normal

abnormal neuronal precursor proliferation ( J:160534 )

• at E12.5, proliferation of mesencephalic dopaminergic neuron progenitor cells is impaired due to premature exit from the cell cycle compared to in wild-type mice

abnormal floor plate morphology ( J:160534 )

• floor plate maturation in the caudal neural tube is impaired, as determined by marker expression, compared to in wild-type mice

decreased dopaminergic neuron number ( J:160534 )

• E12.5, E18.5, and adulthood mice exhibit a reduction in mesencephalic dopaminergic neurons compared with wild-type mice

embryo

abnormal floor plate morphology ( J:160534 )

• floor plate maturation in the caudal neural tube is impaired, as determined by marker expression, compared to in wild-type mice

cellular

abnormal neuron differentiation ( J:160534 )

• mice exhibit impaired neurogenesis in mesencephalic floor plate cells compared with wild-type mice

• however, mesencephalic dopaminergic neuron patterning, specification, and survival are normal

abnormal neuronal precursor proliferation ( J:160534 )

• at E12.5, proliferation of mesencephalic dopaminergic neuron progenitor cells is impaired due to premature exit from the cell cycle compared to in wild-type mice