Phenotypes associated with this allele

• Allele Symbol: Sh2d3c^tm1Lex
• Allele Name: targeted mutation 1, Lexicon Genetics
• Allele ID: MGI:4461024
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sh2d3c^tm1Lex/Sh2d3c^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6	MGI:4461025

Genotype
MGI:4461025

hm1

• Allelic Composition: Sh2d3c^tm1Lex/Sh2d3c^tm1Lex
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal leukocyte migration ( J:161448 )

• the motility of follicular B cells to migrate to CXCL12 is significantly reduced when compared with wild-type cells

• the motility of B cells to migrate to CXCL13 is significantly reduced when compared with wild-type cells

decreased marginal zone B cell number ( J:161448 )

abnormal B cell physiology ( J:161448 )

• decreased proliferation in response to LPS in culture

decreased IgG1 level ( J:161448 )

• reduced TNP-specific Ig on days 7, 14 and 21 after immunization with TNP-Ficoll

decreased IgG2b level ( J:161448 )

• reduced TNP-specific Ig on days 7, 14 and 21 after immunization with TNP-Ficoll

decreased IgG3 level ( J:161448 )

• reduced TNP-specific Ig on days 7, 14 and 21 after immunization with TNP-Ficoll

decreased IgM level ( J:161448 )

• reduced TNP-specific Ig on 21 days after immunization with TNP-Ficoll

abnormal marginal zone B cell physiology ( J:161448 )

• MZB are deficient in their ability to retain antigen

• decreased proliferation in response to LPS in culture

immune system

abnormal leukocyte migration ( J:161448 )

• the motility of follicular B cells to migrate to CXCL12 is significantly reduced when compared with wild-type cells

• the motility of B cells to migrate to CXCL13 is significantly reduced when compared with wild-type cells

decreased marginal zone B cell number ( J:161448 )

abnormal B cell physiology ( J:161448 )

• decreased proliferation in response to LPS in culture

decreased IgG1 level ( J:161448 )

• reduced TNP-specific Ig on days 7, 14 and 21 after immunization with TNP-Ficoll

decreased IgG2b level ( J:161448 )

• reduced TNP-specific Ig on days 7, 14 and 21 after immunization with TNP-Ficoll

decreased IgG3 level ( J:161448 )

• reduced TNP-specific Ig on days 7, 14 and 21 after immunization with TNP-Ficoll

decreased IgM level ( J:161448 )

• reduced TNP-specific Ig on 21 days after immunization with TNP-Ficoll

abnormal marginal zone B cell physiology ( J:161448 )

• MZB are deficient in their ability to retain antigen

• decreased proliferation in response to LPS in culture

abnormal humoral immune response ( J:161448 )

• deficient immune response to thymus-independent type 2 antigens

decreased interleukin-6 secretion ( J:161448 )

• by cultured B cells in response to LPS stimulation

cellular

abnormal leukocyte migration ( J:161448 )

• the motility of follicular B cells to migrate to CXCL12 is significantly reduced when compared with wild-type cells

• the motility of B cells to migrate to CXCL13 is significantly reduced when compared with wild-type cells