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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tnfrsf1atm2.1Rsie
targeted mutation 2.1, Richard M Siegel
MGI:4461135
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tnfrsf1atm2.1Rsie/Tnfrsf1atm2.1Rsie B6.Cg-Tnfrsf1atm2.1Rsie MGI:4461164
ht2
 		Tnfrsf1atm2.1Rsie/Tnfrsf1a+ B6.Cg-Tnfrsf1atm2.1Rsie MGI:4461160
ht3
 		Tnfrsf1atm2.1Rsie/Tnfrsf1a+ involves: 129S6/SvEvTac MGI:4461163


Genotype
MGI:4461164
hm1
Allelic
Composition		 Tnfrsf1atm2.1Rsie/Tnfrsf1atm2.1Rsie
Genetic
Background		 B6.Cg-Tnfrsf1atm2.1Rsie
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf1atm2.1Rsie mutation (0 available); any Tnfrsf1a mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased susceptibility to induced morbidity/mortality ( J:160543 )
• mice treated with LPS and D-galactosamine fail to exhibit induced mortality unlike similarly treated wild-type mice

immune system
abnormal macrophage physiology ( J:160543 )
• TNF-stimulated peritoneal macrophages produce less IL6 and CXCL2 (MIP2) than similarly treated wild-type cells
decreased circulating interleukin-6 level ( J:160543 )
• following LPS challenge
abnormal chemokine secretion ( J:160543 )
• TNF-stimulated peritoneal macrophages produce less CXCL2 (MIP2) than similarly treated wild-type cells
decreased interleukin-6 secretion ( J:160543 )
• TNF-stimulated peritoneal macrophages produce less IL6 than similarly treated wild-type cells
decreased susceptibility to endotoxin shock ( J:160543 )
• mice treated with LPS and D-galactosamine fail to exhibit induced mortality unlike similarly treated wild-type mice

homeostasis/metabolism
decreased circulating interleukin-6 level ( J:160543 )
• following LPS challenge

hematopoietic system
abnormal macrophage physiology ( J:160543 )
• TNF-stimulated peritoneal macrophages produce less IL6 and CXCL2 (MIP2) than similarly treated wild-type cells




Genotype
MGI:4461160
ht2
Allelic
Composition		 Tnfrsf1atm2.1Rsie/Tnfrsf1a+
Genetic
Background		 B6.Cg-Tnfrsf1atm2.1Rsie
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf1atm2.1Rsie mutation (0 available); any Tnfrsf1a mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased susceptibility to induced morbidity/mortality ( J:160543 )
• mice treated with 5 ng/g LPS and D-galactosamine exhibit increased mortality unlike similarly treated wild-type mice
• Background Sensitivity: mice on a C57BL/6 background are less sensitive to LPS and D-galactosamine than mice on a 129S6 background
• however, mortality at 10 ng/g LPS and D-galactosamine is normal

immune system
abnormal macrophage physiology ( J:160543 )
• TNF-stimulated peritoneal macrophages produce less IL6 than similarly treated wild-type cells
decreased circulating interleukin-6 level ( J:160543 )
• following LPS challenge
decreased interleukin-6 secretion ( J:160543 )
• TNF-stimulated peritoneal macrophages produce less IL6 than similarly treated wild-type cells
increased interleukin-6 secretion ( J:160543 )
• LPS-stimulated mouse embryonic fibroblasts exhibit increased IL6 secretion that is enhanced by application of TNFR2-Fc compared with similarly treated wild-type cells
increased susceptibility to endotoxin shock ( J:160543 )
• mice treated with LPS and D-galactosamine exhibit increased mortality unlike similarly treated wild-type mice
• Background Sensitivity: mice on a C57BL/6 background are less sensitive to LPS and D-galactosamine than mice on a 129S6 background
• however, mortality at 10 ng/g LPS and D-galactosamine is normal

homeostasis/metabolism
decreased circulating interleukin-6 level ( J:160543 )
• following LPS challenge

hematopoietic system
abnormal macrophage physiology ( J:160543 )
• TNF-stimulated peritoneal macrophages produce less IL6 than similarly treated wild-type cells

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
autosomal dominant familial periodic fever DOID:0090018 OMIM:142680
 J:160543




Genotype
MGI:4461163
ht3
Allelic
Composition		 Tnfrsf1atm2.1Rsie/Tnfrsf1a+
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf1atm2.1Rsie mutation (0 available); any Tnfrsf1a mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased susceptibility to induced morbidity/mortality ( J:160543 )
• mice treated with 1 ng/g LPS and D-galactosamine exhibit increased mortality unlike similarly treated wild-type mice
• Background Sensitivity: mice on a 129S6 background are more sensitive to LPS and D-galactosamine than mice on a C57BL/6 background

immune system
increased susceptibility to endotoxin shock ( J:160543 )
• mice treated with 1 ng/g LPS and D-galactosamine exhibit increased mortality unlike similarly treated wild-type mice
• Background Sensitivity: mice on a 129S6 background are more sensitive to LPS and D-galactosamine than mice on a C57BL/6 background




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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory