Phenotypes associated with this allele

• Allele Symbol: Olig2^{tm1.1(cre)Wdr}
• Allele Name: targeted mutation 1.1, William D Richardson
• Allele ID: MGI:4461156
• Summary: 7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Acvr1^tm1Mak/Acvr1^+ Gt(ROSA)26Sor^tm9(CAG-tdTomato)Hze/Gt(ROSA)26Sor^+ Olig2^tm1.1(cre)Wdr/Olig2^+	involves: 129 * C57BL/6	MGI:6414954
cn2	Acvr1^tm1Mak/Acvr1^+ Gt(ROSA)26Sor^tm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor^+ Olig2^tm1.1(cre)Wdr/Olig2^+	involves: 129 * C57BL/6 * FVB/N	MGI:6414964
cn3	Acvr1^tm1Mak/Acvr1^+ Gt(ROSA)26Sor^tm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor^+ H3c2^tm1Mak/H3c2^+ Olig2^tm1.1(cre)Wdr/Olig2^+	involves: 129 * C57BL/6 * FVB/N	MGI:6414961
cn4	Gt(ROSA)26Sor^tm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor^+ Olig2^tm1.1(cre)Wdr/Olig2^+	involves: 129 * C57BL/6 * FVB/N	MGI:6414962
cn5	Gt(ROSA)26Sor^tm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor^+ H3c2^tm1Mak/H3c2^+ Olig2^tm1.1(cre)Wdr/Olig2^+	involves: 129 * C57BL/6 * FVB/N	MGI:6414963
cn6	Acvr1^tm1Mak/Acvr1^+ Olig2^tm1.1(cre)Wdr/Olig2^+	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:6414951
cn7	Acvr1^tm1Mak/Acvr1^+ H3c2^tm1Mak/H3c2^+ Olig2^tm1.1(cre)Wdr/Olig2^+	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:6414958

Genotype
MGI:6414954

cn1

• Allelic Composition: Acvr1^tm1Mak/Acvr1⁺; Gt(ROSA)26Sor^{tm9(CAG-tdTomato)Hze}/Gt(ROSA)26Sor⁺; Olig2^{tm1.1(cre)Wdr}/Olig2⁺
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

increased oligodendrocyte number ( J:285841 )

• 2-fold increase in the number of oligodendroglial cells in the ventral brainstem at P7 and P21

Genotype
MGI:6414964

cn2

• Allelic Composition: Acvr1^tm1Mak/Acvr1⁺; Gt(ROSA)26Sor^{tm1(Pik3ca*H1047R)Egan}/Gt(ROSA)26Sor⁺; Olig2^{tm1.1(cre)Wdr}/Olig2⁺
• Genetic Background: involves: 129 * C57BL/6 * FVB/N

neoplasm

increased brain tumor incidence ( J:285841 )

• most mice succumb to spontaneous brain tumors

increased glioma incidence ( J:285841 )

• tumors are high-grade diffuse gliomas

nervous system

increased brain tumor incidence ( J:285841 )

• most mice succumb to spontaneous brain tumors

increased glioma incidence ( J:285841 )

• tumors are high-grade diffuse gliomas

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
brain glioma		DOID:0060108		J:285841

Genotype
MGI:6414961

cn3

• Allelic Composition: Acvr1^tm1Mak/Acvr1⁺; Gt(ROSA)26Sor^{tm1(Pik3ca*H1047R)Egan}/Gt(ROSA)26Sor⁺; H3c2^tm1Mak/H3c2⁺; Olig2^{tm1.1(cre)Wdr}/Olig2⁺
• Genetic Background: involves: 129 * C57BL/6 * FVB/N

neoplasm

increased brain tumor incidence ( J:285841 )

• most mice succumb to spontaneous brain tumors, with a median survival of 419 days

increased glioma incidence ( J:285841 )

• tumors are high-grade diffuse gliomas

• tumors often infiltrate throughout many parts of the brain, particularly in the midbrain and thalamic regions

• tumors express markers of oligodendroglial origin

nervous system

increased brain tumor incidence ( J:285841 )

• most mice succumb to spontaneous brain tumors, with a median survival of 419 days

increased glioma incidence ( J:285841 )

• tumors are high-grade diffuse gliomas

• tumors often infiltrate throughout many parts of the brain, particularly in the midbrain and thalamic regions

• tumors express markers of oligodendroglial origin

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
brain glioma		DOID:0060108		J:285841

Genotype
MGI:6414962

cn4

• Allelic Composition: Gt(ROSA)26Sor^{tm1(Pik3ca*H1047R)Egan}/Gt(ROSA)26Sor⁺; Olig2^{tm1.1(cre)Wdr}/Olig2⁺
• Genetic Background: involves: 129 * C57BL/6 * FVB/N

neoplasm

neoplasm ( J:285841 )

N • mice do not develop brain tumors

Genotype
MGI:6414963

cn5

• Allelic Composition: Gt(ROSA)26Sor^{tm1(Pik3ca*H1047R)Egan}/Gt(ROSA)26Sor⁺; H3c2^tm1Mak/H3c2⁺; Olig2^{tm1.1(cre)Wdr}/Olig2⁺
• Genetic Background: involves: 129 * C57BL/6 * FVB/N

neoplasm

neoplasm ( J:285841 )

N • mice do not develop brain tumors

Genotype
MGI:6414951

cn6

• Allelic Composition: Acvr1^tm1Mak/Acvr1⁺; Olig2^{tm1.1(cre)Wdr}/Olig2⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

mortality/aging

preweaning lethality, incomplete penetrance ( J:285841 )

• some mice fail to gain normal body weight and die before weaning

behavior/neurological

ataxia ( J:285841 )

• surviving mice show moderate ataxia

muscle

muscle spasm ( J:285841 )

• surviving mice show spasms when disrupted during rest

nervous system

abnormal brain development ( J:285841 )

• marker analysis indicates the differentiation of oligodendroglial lineage cells is blocked and neuroglial progenitors are upregulated

abnormal brainstem morphology ( J:285841 )

• higher density of PDGFRA+ cells in brainstems

abnormal glial cell physiology ( J:285841 )

• glial cells exhibit increased growth

neoplasm

neoplasm ( J:285841 )

N • mice do not develop tumors

Genotype
MGI:6414958

cn7

• Allelic Composition: Acvr1^tm1Mak/Acvr1⁺; H3c2^tm1Mak/H3c2⁺; Olig2^{tm1.1(cre)Wdr}/Olig2⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

mortality/aging

postnatal lethality, incomplete penetrance ( J:285841 )

• partial early postnatal lethality

neoplasm

neoplasm ( J:285841 )

N • mice do not develop brain tumors