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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sema6btm1Hfu
targeted mutation 1, Hajime Fujisawa
MGI:4461232
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sema6btm1Hfu/Sema6btm1Hfu involves: 129S/SvEv * C57BL/6J MGI:4461290
cx2
 		Sema6aGt(KST069)Byg/Sema6aGt(KST069)Byg
Sema6btm1Hfu/Sema6btm1Hfu 		involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J MGI:4461294
cx3
 		Plxna2tm1Hfu/Plxna2tm1Hfu
Sema6btm1Hfu/Sema6btm1Hfu 		involves: 129S/SvEv * C57BL/6 * CBA MGI:4461291
cx4
 		Plxna2tm1Hfu/Plxna2tm1Hfu
Sema6btm1Hfu/Sema6b+ 		involves: 129S/SvEv * C57BL/6 * CBA MGI:4461293


Genotype
MGI:4461290
hm1
Allelic
Composition		 Sema6btm1Hfu/Sema6btm1Hfu
Genetic
Background		 involves: 129S/SvEv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sema6btm1Hfu mutation (0 available); any Sema6b mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal hippocampal mossy fiber morphology ( J:160509 )
• suprapyramidal bundles are thicker while infrapyramidal bundles are longer than in wild-type mice
• mossy fiber spreading from the suprapyramidal and infrapyramidal bundles into the stratum radiatum and stratum oriens is inappropriate compared to in wild-type mice
• mossy fiber projections of P5 hippocampal slices cultured for 5 days exhibit very thin suprapyramidal bundles and spread widely within the stratum radiatum compared projections from wild-type cultures
• whether CA3 slices are cocultured with dentate gyrus slices from wild-type or Sema6btm1Hfu mice, mossy fibers spread abnormally into the stratum radiatum unlike similarly treated wild-type CA3 slices
• mossy fibers invade the inner molecular layer of the dentate gyrus unlike in wild-type mice
• mice exhibit abnormal projection of mossy cell axons compared to in wild-type mice




Genotype
MGI:4461294
cx2
Allelic
Composition		 Sema6aGt(KST069)Byg/Sema6aGt(KST069)Byg
Sema6btm1Hfu/Sema6btm1Hfu
Genetic
Background		 involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sema6aGt(KST069)Byg mutation (1 available); any Sema6a mutation (85 available)
Sema6btm1Hfu mutation (0 available); any Sema6b mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal hippocampal mossy fiber morphology ( J:160509 )
• the suprapyramidal bundle is thicker and the infrapyramidal bundle is longer than in Sema6btm1Hfu homozygotes
• more mossy fibers aberrantly spread into the stratum radiatum and stratum oriens compared to in Sema6btm1Hfu homozygotes
• however, mossy fiber spread into the stratum lacunosum-moleculare is normal
• mossy fibers invade the inner molecular layer of the dentate gyrus unlike in wild-type mice




Genotype
MGI:4461291
cx3
Allelic
Composition		 Plxna2tm1Hfu/Plxna2tm1Hfu
Sema6btm1Hfu/Sema6btm1Hfu
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plxna2tm1Hfu mutation (1 available); any Plxna2 mutation (130 available)
Sema6btm1Hfu mutation (0 available); any Sema6b mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal hippocampal mossy fiber morphology ( J:160509 )
• mossy fibers initially grow into the proximal parts of the infrapyramidal region and stratum pyramidalis of CA3c and eventually invade proximal parts of the suprapyramidal region of CA3ab to form the thinner suprapyramidal bundle compared to in wild-type mice
• some mossy fibers directly invade the stratum radiatum and stratum oriens of the CA3c and sometimes grow into the stratum pyramidalis of CA1 unlike in wild-type mice
• the suprapyramidal bundle is thinner than in wild-type mice and Plxna2tm1Hfu Sema6aGt(KST069)Byg double homozygotes




Genotype
MGI:4461293
cx4
Allelic
Composition		 Plxna2tm1Hfu/Plxna2tm1Hfu
Sema6btm1Hfu/Sema6b+
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plxna2tm1Hfu mutation (1 available); any Plxna2 mutation (130 available)
Sema6btm1Hfu mutation (0 available); any Sema6b mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal hippocampal mossy fiber morphology ( J:160509 )
• mossy fibers are restricted to proximal parts of the infrapyramidal region and stratum pyramidalis in most parts of CA3, except distal CA3ab, and form a very thin suprapyramidal bundle compared to in wild-type mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory