All Phenotypes Ar<tm2Ska> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ar^tm2Ska
targeted mutation 2, Shigeaki Kato
MGI:4461236

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ar^tm2Ska/Ar^tm2Ska Pax7^{tm2.1(cre/ERT2)Fan}/Pax7⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrl	MGI:7647262
cn2	Ar^tm2Ska/Y Shh^{tm2(cre/ERT2)Cjt}/Shh⁺	involves: 129S6/SvEvTac * C57BL/6 * CBA	MGI:4461253
cn3	Ar^tm2Ska/Y Gli1^{tm3(cre/ERT2)Alj}/Gli1⁺	involves: 129S6/SvEvTac * C57BL/6 * CBA	MGI:4461249
cn4	Ar^tm2Ska/Y Tg(KRT5-cre)1Tak/0	involves: C3H * C57BL/6 * CBA	MGI:4461252
cn5	Ar^tm2Ska/Ar^tm2Ska Tg(ACTA1-cre)79Jme/0	involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj * SJL	MGI:7647260

Allelic Composition	Ar^tm2Ska/Ar^tm2Ska Pax7^{tm2.1(cre/ERT2)Fan}/Pax7⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6NCrlj * CBA/JNCrl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ar^tm2Ska mutation (0 available); any Ar mutation (22 available)
Pax7^{tm2.1(cre/ERT2)Fan} mutation (1 available); any Pax7 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

muscle phenotype ( J:316008 )

N	• 9-week-old tamoxifen-treated females implanted with a biodegradable pellet containing 10 mg dihydrotestostorone (DHT) to induce muscle hypertrophy show a similar increase in tibialis anterior, quadriceps, and gastrocnemius muscle mass as wild-type mice

Allelic Composition	Ar^tm2Ska/Y Shh^{tm2(cre/ERT2)Cjt}/Shh⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ar^tm2Ska mutation (0 available); any Ar mutation (22 available)
Shh^{tm2(cre/ERT2)Cjt} mutation (1 available); any Shh mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:148515 )

N	• tamoxifen-treated mice exhibit normal masculinization

Allelic Composition	Ar^tm2Ska/Y Gli1^{tm3(cre/ERT2)Alj}/Gli1⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ar^tm2Ska mutation (0 available); any Ar mutation (22 available)
Gli1^{tm3(cre/ERT2)Alj} mutation (2 available); any Gli1 mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal external male genitalia morphology ( J:148515 )

• tamoxifen-treated mice exhibit hypoplastic external genitalia compared with wild-type mice

• external genitalis of tamoxifen-treated mice are feminized

abnormal foreskin morphology ( J:148515 )

• underdeveloped in tamoxifen-treated mice

abnormal reproductive system development ( J:148515 )

• prospective corporal bodies from tamoxifen-treated mice fail to differentiate or bilaterally segment in the mesenchyme unlike in wild-type mice

• however, development of internal reproductive organs are normally in tamoxifen-treated mice

renal/urinary system

abnormal foreskin morphology ( J:148515 )

• underdeveloped in tamoxifen-treated mice

Allelic Composition	Ar^tm2Ska/Y Tg(KRT5-cre)1Tak/0
Genetic Background	involves: C3H * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ar^tm2Ska mutation (0 available); any Ar mutation (22 available)
Tg(KRT5-cre)1Tak mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:148515 )

N	• mice exhibit normal masculinization

Allelic Composition	Ar^tm2Ska/Ar^tm2Ska Tg(ACTA1-cre)79Jme/0
Genetic Background	involves: C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ar^tm2Ska mutation (0 available); any Ar mutation (22 available)
Tg(ACTA1-cre)79Jme mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

decreased grip strength ( J:316008 )

• 9-week-old females implanted with a biodegradable pellet containing 10 mg dihydrotestostorone (DHT) to induce muscle hypertrophy do not show an increase in grip strength as is seen in wild-type mice with the DHT pellet

• however, body weight and skeletal muscle weight are increased by DHT treatment to the same extent as in wild-type mice indicating decreased muscle strength

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