All Phenotypes Hoxa3<tm2Nrm> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hoxa3^tm2Nrm
targeted mutation 2, Nancy R Manley
MGI:4461300

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hoxa3^tm2Nrm/Hoxa3^tm2Nrm	involves: C3H * C57BL/6 * C57BL/6NHsd	MGI:4461318
ht2	Hoxa3^tm1Mrc/Hoxa3^tm2Nrm	involves: 129S7/SvEvBrd * C3H * C57BL/6 * C57BL/6NHsd	MGI:4461317
cn3	Hoxa3^tm2Nrm/Hoxa3^tm3.1Nrm H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺	involves: C3H * C57BL/6 * CBA/J	MGI:4461313
cx4	Hoxa3^tm2Nrm/Hoxa3⁺ Hoxd3^tm1Mrc/Hoxd3^tm1Mrc	involves: 129S7/SvEvBrd * C3H * C57BL/6 * C57BL/6NHsd	MGI:4461314
cx5	Hoxa3^tm2Nrm/Hoxa3^tm2Nrm Hoxd3^tm1Mrc/Hoxd3^tm1Mrc	involves: 129S7/SvEvBrd * C3H * C57BL/6 * C57BL/6NHsd	MGI:4461315

Allelic Composition	Hoxa3^tm2Nrm/Hoxa3^tm2Nrm
Genetic Background	involves: C3H * C57BL/6 * C57BL/6NHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa3^tm2Nrm mutation (0 available); any Hoxa3 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality ( J:161296 )

craniofacial

craniofacial phenotype ( J:161296 )

N	• mice exhibit a normal soft palate

abnormal hyoid bone greater horn morphology ( J:161296 )

• the greater horn of the hyoid bone is malformed and fused to the thyroid cartilage unlike in wild-type mice

abnormal hyoid bone lesser horn morphology ( J:161296 )

• the lesser horn of the hyoid bone is more square than in wild-type mice and contains an extra cartilage extension from the great horn back to the base of the skull unlike in wild-type mice

nervous system

abnormal glossopharyngeal nerve morphology ( J:161296 )

• the glossopharyngeal nerve is either fused to the vagus nerve or disconnected from the hind brain unlike in wild-type mice

fusion of glossopharyngeal and vagus nerve ( J:161296 )

• in some mice

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:161296 )

N	• unlike in null mice, the ventral thyroid isthmus and ultimobranchial are normal

absent parathyroid glands ( J:161296 )

athymia ( J:161296 )

immune system

athymia ( J:161296 )

respiratory system

respiratory system phenotype ( J:161296 )

N	• unlike in null mice, tracheal epithelia is normal

digestive/alimentary system

digestive/alimentary phenotype ( J:161296 )

N	• mice exhibit a normal soft palate

growth/size/body

growth/size/body region phenotype ( J:161296 )

N	• mice exhibit a normal abdomen

hematopoietic system

athymia ( J:161296 )

skeleton

abnormal hyoid bone greater horn morphology ( J:161296 )

• the greater horn of the hyoid bone is malformed and fused to the thyroid cartilage unlike in wild-type mice

abnormal hyoid bone lesser horn morphology ( J:161296 )

• the lesser horn of the hyoid bone is more square than in wild-type mice and contains an extra cartilage extension from the great horn back to the base of the skull unlike in wild-type mice

Allelic Composition	Hoxa3^tm1Mrc/Hoxa3^tm2Nrm
Genetic Background	involves: 129S7/SvEvBrd * C3H * C57BL/6 * C57BL/6NHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa3^tm1Mrc mutation (0 available); any Hoxa3 mutation (24 available)
Hoxa3^tm2Nrm mutation (0 available); any Hoxa3 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality ( J:161296 )

craniofacial

craniofacial phenotype ( J:161296 )

N	• mice exhibit a normal soft palate

abnormal hyoid bone greater horn morphology ( J:161296 )

abnormal hyoid bone lesser horn morphology ( J:161296 )

nervous system

abnormal glossopharyngeal nerve morphology ( J:161296 )

• the glossopharyngeal nerve is either fused to the vagus nerve or disconnected from the hind brain unlike in wild-type mice

fusion of glossopharyngeal and vagus nerve ( J:161296 )

• in some mice

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:161296 )

N	• unlike in null mice, the ventral thyroid isthmus and ultimobranchial are normal

absent parathyroid glands ( J:161296 )

athymia ( J:161296 )

immune system

athymia ( J:161296 )

respiratory system

respiratory system phenotype ( J:161296 )

N	• unlike in null mice, tracheal epithelia is normal

digestive/alimentary system

digestive/alimentary phenotype ( J:161296 )

N	• mice exhibit a normal soft palate

growth/size/body

growth/size/body region phenotype ( J:161296 )

N	• mice exhibit a normal abdomen

hematopoietic system

athymia ( J:161296 )

skeleton

abnormal hyoid bone greater horn morphology ( J:161296 )

abnormal hyoid bone lesser horn morphology ( J:161296 )

Allelic Composition	Hoxa3^tm2Nrm/Hoxa3^tm3.1Nrm H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
Genetic Background	involves: C3H * C57BL/6 * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2^{Tg(Wnt1-cre)11Rth} mutation (2 available); any H2az2 mutation (26 available)
Hoxa3^tm2Nrm mutation (0 available); any Hoxa3 mutation (24 available)
Hoxa3^tm3.1Nrm mutation (0 available); any Hoxa3 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

ectopic parathyroid gland ( J:161296 )

• at E15.5, parathyroids are ectopically attached to the thymus unlike in wild-type mice

• however, parathyroid morphology is normal

ectopic thymus ( J:161296 )

• at E15.5, thymic lobes are absent from their normal position and are ectopically attached to the pharynx unlike in wild-type mice

• however, thymic lobe morphology is normal

immune system

ectopic thymus ( J:161296 )

• at E15.5, thymic lobes are absent from their normal position and are ectopically attached to the pharynx unlike in wild-type mice

• however, thymic lobe morphology is normal

hematopoietic system

ectopic thymus ( J:161296 )

• at E15.5, thymic lobes are absent from their normal position and are ectopically attached to the pharynx unlike in wild-type mice

• however, thymic lobe morphology is normal

Allelic Composition	Hoxa3^tm2Nrm/Hoxa3⁺ Hoxd3^tm1Mrc/Hoxd3^tm1Mrc
Genetic Background	involves: 129S7/SvEvBrd * C3H * C57BL/6 * C57BL/6NHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa3^tm2Nrm mutation (0 available); any Hoxa3 mutation (24 available)
Hoxd3^tm1Mrc mutation (0 available); any Hoxd3 mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal axial skeleton morphology ( J:161296 )

• authors state than mice resemble Hoxd3^tm1Mrc homozygotes

Allelic Composition	Hoxa3^tm2Nrm/Hoxa3^tm2Nrm Hoxd3^tm1Mrc/Hoxd3^tm1Mrc
Genetic Background	involves: 129S7/SvEvBrd * C3H * C57BL/6 * C57BL/6NHsd

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal basioccipital bone morphology ( J:161296 )

absent cervical atlas ( J:161296 )

• absent

craniofacial

abnormal basioccipital bone morphology ( J:161296 )

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