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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hoxa3tm3.1Nrm
targeted mutation 3.1, Nancy R Manley
MGI:4461308
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Hoxa3tm1Mrc/Hoxa3tm3.1Nrm
H2az2Tg(Wnt1-cre)11Rth/H2az2+ 		involves: 129S7/SvEvBrd * C57BL/6J * CBA/J MGI:4461312
cn2
 		Hoxa3tm2Nrm/Hoxa3tm3.1Nrm
H2az2Tg(Wnt1-cre)11Rth/H2az2+ 		involves: C3H * C57BL/6 * CBA/J MGI:4461313


Genotype
MGI:4461312
cn1
Allelic
Composition		 Hoxa3tm1Mrc/Hoxa3tm3.1Nrm
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
Hoxa3tm1Mrc mutation (0 available); any Hoxa3 mutation (24 available)
Hoxa3tm3.1Nrm mutation (0 available); any Hoxa3 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
ectopic parathyroid gland ( J:161296 )
• at E15.5, parathyroids are ectopically attached to the thymus unlike in wild-type mice
• however, parathyroid morphology is normal
ectopic thymus ( J:161296 )
• at E15.5, thymic lobes are absent from their normal position and are ectopically attached to the pharynx unlike in wild-type mice
• however, thymic lobe morphology is normal

hematopoietic system
ectopic thymus ( J:161296 )
• at E15.5, thymic lobes are absent from their normal position and are ectopically attached to the pharynx unlike in wild-type mice
• however, thymic lobe morphology is normal

immune system
ectopic thymus ( J:161296 )
• at E15.5, thymic lobes are absent from their normal position and are ectopically attached to the pharynx unlike in wild-type mice
• however, thymic lobe morphology is normal




Genotype
MGI:4461313
cn2
Allelic
Composition		 Hoxa3tm2Nrm/Hoxa3tm3.1Nrm
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background		 involves: C3H * C57BL/6 * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
Hoxa3tm2Nrm mutation (0 available); any Hoxa3 mutation (24 available)
Hoxa3tm3.1Nrm mutation (0 available); any Hoxa3 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
ectopic parathyroid gland ( J:161296 )
• at E15.5, parathyroids are ectopically attached to the thymus unlike in wild-type mice
• however, parathyroid morphology is normal
ectopic thymus ( J:161296 )
• at E15.5, thymic lobes are absent from their normal position and are ectopically attached to the pharynx unlike in wild-type mice
• however, thymic lobe morphology is normal

immune system
ectopic thymus ( J:161296 )
• at E15.5, thymic lobes are absent from their normal position and are ectopically attached to the pharynx unlike in wild-type mice
• however, thymic lobe morphology is normal

hematopoietic system
ectopic thymus ( J:161296 )
• at E15.5, thymic lobes are absent from their normal position and are ectopically attached to the pharynx unlike in wild-type mice
• however, thymic lobe morphology is normal




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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory