Phenotypes associated with this allele

• Allele Symbol: Tg(RP23-326M22)760She
• Allele Name: transgene insertion 760, Sarah Elsea
• Allele ID: MGI:4461458
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(RP23-326M22)760She/Tg(RP23-326M22)760She	B6.Cg-Tg(RP23-326M22)760She	MGI:4462243
tg2	Tg(RP23-326M22)760She/0	B6.Cg-Tg(RP23-326M22)760She	MGI:4462240

Genotype
MGI:4462243

tg1

• Allelic Composition: Tg(RP23-326M22)760She/Tg(RP23-326M22)760She
• Genetic Background: B6.Cg-Tg(RP23-326M22)760She

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

increased anxiety-related response ( J:161765 )

impaired coordination ( J:161765 )

decreased grip strength ( J:161765 )

• decreased forelimb grip strength in comparison to hemizygotes and controls

abnormal locomotor behavior ( J:161765 )

• increased motor activity as determined by number of interruptions to photo cell beams

decreased vertical activity ( J:161765 )

• reduced rearing activity

hyperactivity ( J:161765 )

• mice are very active and difficult to handle

abnormal sensory capabilities/reflexes/nociception ( J:161765 )

• heightened approach response (approach with a blunt object)

impaired righting response ( J:161765 )

growth/size/body

decreased body weight ( J:161765 )

postnatal growth retardation ( J:161765 )

• mice are slender and small

• growth retardation in homozygotes is significantly reduced compared to hemizygotes and controls

reproductive system

reduced female fertility ( J:161765 )

♀

reduced male fertility ( J:161765 )

♂

Genotype
MGI:4462240

tg2

• Allelic Composition: Tg(RP23-326M22)760She/0
• Genetic Background: B6.Cg-Tg(RP23-326M22)760She

behavior/neurological

increased anxiety-related response ( J:161765 )

• mice spend a decreased proportion of time in the center of the open field test

impaired righting response ( J:161765 )

hyperresponsive to tactile stimuli ( J:161765 )

• although not statistically significant, 20 week old mice exhibited hyper-responsiveness to both the hotplate and tail flick tests

impaired coordination ( J:161765 )

• in response to the cage-top hang test, 20 week old mice easily fall off the cage-top

decreased grip strength ( J:161765 )

• decreased forelimb grip strength

abnormal posture ( J:161765 )

• shortened stance

abnormal locomotor behavior ( J:161765 )

• increased motor activity as determined by number of interruptions to photo cell beams

abnormal gait ( J:161765 )

• mice exhibit a shorter, wider gait and an increased sway distance

short stride length ( J:161765 )

decreased vertical activity ( J:161765 )

• decreased rearing behavior at 10 and 20 weeks, although behavior is similar to controls at 5 weeks

increased locomotor activity ( J:161765 )

• mice exhibit overtly active, wild running behavior

• mice exhibit increased motor activity at 5 and 10 weeks, but behave similarly to controls by 20 weeks

abnormal social/conspecific interaction behavior ( J:161765 )

• transgenics are socially dominant compared to nontransgenics as determined by the tube test

liver/biliary system

abnormal hepatocyte morphology ( J:161765 )

• hepatocytes contain a large nucleus altering the nucleus:cytoplasm ratio, however, levels of liver enzymes are similar to controls

growth/size/body

decreased body size ( J:161765 )

• proportionally decreased head and body size as compared to controls

decreased body weight ( J:161765 )

• mice exhibit decreased body weight up to 20 weeks of age, but weight is similar to controls at 30 weeks

decreased body length ( J:161765 )

• mice exhibit decreased body length up to 20 weeks of age, but are similar to controls at 30 weeks

postnatal growth retardation ( J:161765 )

• males exhibit greater growth retardation than females

reproductive system

reduced female fertility ( J:161765 )

♀