All Phenotypes Oxr1<tm1a(EUCOMM)Wtsi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Oxr1^{tm1a(EUCOMM)Wtsi}
targeted mutation 1a, Wellcome Trust Sanger Institute
MGI:4461745

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Oxr1^{tm1a(EUCOMM)Wtsi}/Oxr1^{tm1a(EUCOMM)Wtsi}	C57BL/6N-Oxr1^{tm1a(EUCOMM)Wtsi}	MGI:5796653
ht2	Oxr1^{tm1a(EUCOMM)Wtsi}/Oxr1⁺	C57BL/6N-Oxr1^{tm1a(EUCOMM)Wtsi}/Wtsi	MGI:6461506
cx3	Ncoa7^em1Pelo/Ncoa7⁺ Oxr1^{tm1a(EUCOMM)Wtsi}/Oxr1^{tm1a(EUCOMM)Wtsi}	involves: C57BL/6J * C57BL/6N	MGI:6714042
cx4	Ncoa7^em1Pelo/Ncoa7^em1Pelo Oxr1^{tm1a(EUCOMM)Wtsi}/Oxr1^{tm1a(EUCOMM)Wtsi}	involves: C57BL/6J * C57BL/6N	MGI:6714043

Allelic Composition	Oxr1^{tm1a(EUCOMM)Wtsi}/Oxr1^{tm1a(EUCOMM)Wtsi}
Genetic Background	C57BL/6N-Oxr1^{tm1a(EUCOMM)Wtsi}

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Oxr1^{tm1a(EUCOMM)Wtsi} mutation (1 available); any Oxr1 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Oxr1^{tm1a(EUCOMM)Wtsi}/Oxr1^{tm1a(EUCOMM)Wtsi} and bella/bella mice show increased apoptosis in the granule cell layer of the cerebellum

mortality/aging

premature death ( J:230923 )

behavior/neurological

ataxia ( J:230923 )

• homozygotes display ataxia to the same extent and over an identical time course as bella homozygotes

nervous system

increased neuron apoptosis ( J:230923 )

• at P21, homozygotes show a significant increase in TUNEL-positive cells in the granule cell layer of the cerebellum with a pattern and distribution equivalent to that seen in bella homozygotes

neurodegeneration ( J:230923 )

• homozygotes display progressive cerebellar degeneration to the same extent and over an identical time course as bella homozygotes

cellular

increased neuron apoptosis ( J:230923 )

• at P21, homozygotes show a significant increase in TUNEL-positive cells in the granule cell layer of the cerebellum with a pattern and distribution equivalent to that seen in bella homozygotes

Allelic Composition	Oxr1^{tm1a(EUCOMM)Wtsi}/Oxr1⁺
Genetic Background	C57BL/6N-Oxr1^{tm1a(EUCOMM)Wtsi}/Wtsi
Cell Lines	EPD0600_1_B09

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Oxr1^{tm1a(EUCOMM)Wtsi} mutation (1 available); any Oxr1 mutation (37 available)

Data Sources

IMPC Data for Oxr1

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body length ( J:211773 )

IMPC - WTSI

hematopoietic system

thrombocytopenia ( J:211773 )

IMPC - WTSI

Allelic Composition	Ncoa7^em1Pelo/Ncoa7⁺ Oxr1^{tm1a(EUCOMM)Wtsi}/Oxr1^{tm1a(EUCOMM)Wtsi}
Genetic Background	involves: C57BL/6J * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ncoa7^em1Pelo mutation (0 available); any Ncoa7 mutation (199 available)
Oxr1^{tm1a(EUCOMM)Wtsi} mutation (1 available); any Oxr1 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

ataxia ( J:305611 )

• early-onset

Allelic Composition	Ncoa7^em1Pelo/Ncoa7^em1Pelo Oxr1^{tm1a(EUCOMM)Wtsi}/Oxr1^{tm1a(EUCOMM)Wtsi}
Genetic Background	involves: C57BL/6J * C57BL/6N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:305611 )

• no embryos found at stage E8.5-9.5

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