Phenotypes associated with this allele

• Allele Symbol: Oxr1^{tm1a(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4461745
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Oxr1^tm1a(EUCOMM)Wtsi/Oxr1^tm1a(EUCOMM)Wtsi	C57BL/6N-Oxr1^tm1a(EUCOMM)Wtsi	MGI:5796653
ht2	Oxr1^tm1a(EUCOMM)Wtsi/Oxr1^+	C57BL/6N-Oxr1^tm1a(EUCOMM)Wtsi/Wtsi	MGI:6461506
cx3	Ncoa7^em1Pelo/Ncoa7^+ Oxr1^tm1a(EUCOMM)Wtsi/Oxr1^tm1a(EUCOMM)Wtsi	involves: C57BL/6J * C57BL/6N	MGI:6714042
cx4	Ncoa7^em1Pelo/Ncoa7^em1Pelo Oxr1^tm1a(EUCOMM)Wtsi/Oxr1^tm1a(EUCOMM)Wtsi	involves: C57BL/6J * C57BL/6N	MGI:6714043

Genotype
MGI:5796653

hm1

• Allelic Composition: Oxr1^{tm1a(EUCOMM)Wtsi}/Oxr1^{tm1a(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Oxr1^{tm1a(EUCOMM)Wtsi}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Oxr1^{tm1a(EUCOMM)Wtsi}/Oxr1^{tm1a(EUCOMM)Wtsi} and bella/bella mice show increased apoptosis in the granule cell layer of the cerebellum

mortality/aging

premature death ( J:230923 )

behavior/neurological

ataxia ( J:230923 )

• homozygotes display ataxia to the same extent and over an identical time course as bella homozygotes

nervous system

increased neuron apoptosis ( J:230923 )

• at P21, homozygotes show a significant increase in TUNEL-positive cells in the granule cell layer of the cerebellum with a pattern and distribution equivalent to that seen in bella homozygotes

neurodegeneration ( J:230923 )

• homozygotes display progressive cerebellar degeneration to the same extent and over an identical time course as bella homozygotes

cellular

increased neuron apoptosis ( J:230923 )

• at P21, homozygotes show a significant increase in TUNEL-positive cells in the granule cell layer of the cerebellum with a pattern and distribution equivalent to that seen in bella homozygotes

Genotype
MGI:6461506

ht2

• Allelic Composition: Oxr1^{tm1a(EUCOMM)Wtsi}/Oxr1⁺
• Genetic Background: C57BL/6N-Oxr1^{tm1a(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0600_1_B09

Data Sources

IMPC Data for Oxr1

growth/size/body

decreased body length ( J:211773 )

♀

IMPC - WTSI

hematopoietic system

thrombocytopenia ( J:211773 )

♂

IMPC - WTSI

Genotype
MGI:6714042

cx3

• Allelic Composition: Ncoa7^em1Pelo/Ncoa7⁺; Oxr1^{tm1a(EUCOMM)Wtsi}/Oxr1^{tm1a(EUCOMM)Wtsi}
• Genetic Background: involves: C57BL/6J * C57BL/6N

behavior/neurological

ataxia ( J:305611 )

• early-onset

Genotype
MGI:6714043

cx4

• Allelic Composition: Ncoa7^em1Pelo/Ncoa7^em1Pelo; Oxr1^{tm1a(EUCOMM)Wtsi}/Oxr1^{tm1a(EUCOMM)Wtsi}
• Genetic Background: involves: C57BL/6J * C57BL/6N

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:305611 )

• no embryos found at stage E8.5-9.5