Phenotypes associated with this allele

• Allele Symbol: Cbfb^tm3Ppl
• Allele Name: targeted mutation 3, Pu P Liu
• Allele ID: MGI:4461804
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Cbfb^tm3Ppl/Cbfb^+	involves: 129S6/SvEvTac * C57BL/6	MGI:4461978

Genotype
MGI:4461978

ht1

• Allelic Composition: Cbfb^tm3Ppl/Cbfb⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:160522 )

• several pups survive to at least E13.5

• one embryo found at E16.5 with no signs of hemorrhage

postnatal lethality, complete penetrance ( J:160522 )

• heterozygotes die by 10-18 days of age

prenatal lethality, incomplete penetrance ( J:160522 )

• most heterozygous pups die before birth, 2 out of 25 pups are born alive

cardiovascular system

internal hemorrhage ( J:160522 )

• E12.5 embryos develop multiple hemorrhages in the central nervous system

liver/biliary system

pale liver ( J:160522 )

• pale liver at E12.5- E13.5

hematopoietic system

hematopoietic system phenotype ( J:160522 )

N • hematopoietic progenitors clearly visible in liver sections

N • megakaryocytes found in the liver

decreased hematopoietic stem cell number ( J:160522 )

• reduced in-vitro hematopoietic colony formation