Analysis Tools|
Allele Symbol Allele Name Allele ID |
Pank1tm1.1Suja targeted mutation 1.1, Suzanne Jackowski MGI:4462018 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• reduced Co-A-dependent fatty acid oxidation in the liver
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• reduced Co-A-dependent fatty acid oxidation in the liver
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• increased body weight at 16 weeks old
• gain more weight as they age after 13 weeks old compared to wild-type
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• significantly higher acetyl-carnitine levels in the livers in both the fed and fasted states
• striking accumulation of >C10 acyl-carnitines in the livers in both the fed and fasted states
• increased C16:0, C18:0 and C18:1 acyl-carnitines in the livers following a 48 h fast
• minor differences in the 3- and 4-carbon acyl-carnitines in the livers
• normal free carnitine level in the livers
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• lower 14-hour fasted serum glucose levels
• lower serum glucose levels after 12h, 24h and 48h fast
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• severely compromised gluconeogenesis in the pyruvate challenge experiment
• severely compromised gluconeogenesis in their response to oxaloacetate or glycerol in an oxaloacetate challenge and a glycerol challenge
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• lower blood triglycerides levels after an overnight (14 h) fast
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• lower levels of triglycerides than wild-type mice in the fed state
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• consistently 5 times higher than in the wild-type controls after 48h fast
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• lower free Coenzyme A (CoA) than wild-type livers under both fed and fasted conditions
(J:161798)
• marked increase in long-chain acyl-CoAs in the livers after a 48 h fast
(J:161798)
• reduced capacity for oxidation in the fasted livers compared to wild-type
(J:161798)
• the fatty acid oxidation capacity remains the same as in the fed state after a 48h fast
(J:161798)
• no increased free CoA during fasting
(J:161798)
• lower trend in short-chain acyl-CoA levels than wild-type livers under both fed and fasted conditions
(J:161798)
• modestly increased trend in short-chain acyl-CoA levels in the liver during a 48 h fast
(J:161798)
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• eat significantly more food than the wild-type
• same percentage of fat retains as the wild-type
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• lower levels of triglycerides than wild-type mice in the fed state
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• consistently 5 times higher than in the wild-type controls after 48h fast
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• numerous cellular neutral lipid droplets inclusions following a 48 h fast
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• reduced capacity for fatty acid oxidation in hepatocytes
• impaired fatty acid degradation
• significantly higher acetyl-carnitine levels in the livers in both the fed and fasted states
• striking accumulation of >C10 acyl-carnitines in both the fed and fasted states
• increased C16:0, C18:0 and C18:1 acyl-carnitines following a 48 h fast
• minor differences in the 3- and 4-carbon acyl-carnitines
• normal free carnitine level
• normal number of mitochondria
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Small size of Pank1tm1.1Suja/Pank1tm1.1Suja Pank2tm1.1Suja/Pank2tm1.1Suja mice
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• mice die within 18 days of birth
• not rescued by glucose injection
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• after P7
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• after P7
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• after P7
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• at P10
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• at P10
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• mice drag hind limbs for extended periods between the first and second weeks of birth
• however, this phenotype is resolved before the onset of morbidity leading to death
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• mice drag hind limbs for extended periods between the first and second weeks of birth
• however, this phenotype is resolved before the onset of morbidity leading to death
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• reduced Co-A-dependent fatty acid oxidation in the liver
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• by P10
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• at P10 and P14 due to reduced ketone utilization
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• mice exhibit altered fatty acid profile in the liver (reduced palmitoleic acid, oleic acid, alpha-linoleic acid and increased stearic acid) compared with wild-type mice
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• at P10
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• at P10
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• mice drag hind limbs for extended periods between the first and second weeks of birth
• however, this phenotype is resolved before the onset of morbidity leading to death
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• at P10
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• at P10
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• reduced Co-A-dependent fatty acid oxidation in the liver
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• at P10
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• at P10
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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