adipose tissue
• at 6 months when fed standard chow despite normal food intake, fasting glucose, bone mineral density and lean mass
• when fed a high-fat diet despite no increase in food intake
• however, rapamycin treatment reduced fat mass
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• when fed standard chow or a high-fat diet
• however, cell number is normal and rapamycin treatment reduced cell size
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• brown adipose tissue exhibit larger multilocular lipid droplets compared to in control mice
• however, rapamycin treatment reduced lipid accumulation in brown adipose tissue
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• in epididymal and inguinal white adipose tissue when fed standard chow or a high-fat diet
• however, cell number is normal and rapamycin treatment reduced cell size
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• enlarged
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• increased lipid accumulation
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• reduced beta-adrenoceptor agonist-stimulated glycerol and fatty acid release from brown, inguinal and epididymal fat of fasted mice
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• decreased fatty acid oxidation in brown adipocytes
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homeostasis/metabolism
• in brown adipocytes
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• when fed a high-fat diet despite no increase in food intake
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• cold-exposed mice exhibit reduced body temperatures compared with control mice
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• when fed a high-fat diet
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• in cold-exposed mice
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• in cold-exposed mice despite normal activity levels and respiratory quotient
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• when fed a high-fat diet
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• when fed a high-fat diet
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growth/size/body
• at 6 months when fed standard chow despite normal food intake, fasting glucose, bone mineral density and lean mass
• when fed a high-fat diet despite no increase in food intake
• however, rapamycin treatment reduced fat mass
|
• at 6 months despite normal food intake, fasting glucose, bone mineral density and lean mass
• however, rapamycin treatment reduced body weight gain
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• at 6 months
• however, rapamycin treatment reduced body weight gain
|
• when fed a high-fat diet despite no increase in food intake
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liver/biliary system
• when fed a high-fat diet
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cellular
• in brown adipocytes
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