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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Adipoq-cre)#Pesch
transgene insertion, Philipp E Scherer
MGI:4462047
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Grb10tm1.1Fliu/Grb10tm1.1Fliu
Tg(Adipoq-cre)#Pesch/0
involves: 129S/SvEv * FVB MGI:6107175


Genotype
MGI:6107175
cn1
Allelic
Composition
Grb10tm1.1Fliu/Grb10tm1.1Fliu
Tg(Adipoq-cre)#Pesch/0
Genetic
Background
involves: 129S/SvEv * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grb10tm1.1Fliu mutation (0 available); any Grb10 mutation (56 available)
Tg(Adipoq-cre)#Pesch mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue
• at 6 months when fed standard chow despite normal food intake, fasting glucose, bone mineral density and lean mass
• when fed a high-fat diet despite no increase in food intake
• however, rapamycin treatment reduced fat mass
• when fed standard chow or a high-fat diet
• however, cell number is normal and rapamycin treatment reduced cell size
• brown adipose tissue exhibit larger multilocular lipid droplets compared to in control mice
• however, rapamycin treatment reduced lipid accumulation in brown adipose tissue
• in epididymal and inguinal white adipose tissue when fed standard chow or a high-fat diet
• however, cell number is normal and rapamycin treatment reduced cell size
• increased lipid accumulation
• reduced beta-adrenoceptor agonist-stimulated glycerol and fatty acid release from brown, inguinal and epididymal fat of fasted mice
• decreased fatty acid oxidation in brown adipocytes

homeostasis/metabolism
• in brown adipocytes
• when fed a high-fat diet despite no increase in food intake
• cold-exposed mice exhibit reduced body temperatures compared with control mice
• when fed a high-fat diet
• in cold-exposed mice
• in cold-exposed mice despite normal activity levels and respiratory quotient
• when fed a high-fat diet
• when fed a high-fat diet

growth/size/body
• at 6 months when fed standard chow despite normal food intake, fasting glucose, bone mineral density and lean mass
• when fed a high-fat diet despite no increase in food intake
• however, rapamycin treatment reduced fat mass
• at 6 months despite normal food intake, fasting glucose, bone mineral density and lean mass
• however, rapamycin treatment reduced body weight gain
• at 6 months
• however, rapamycin treatment reduced body weight gain
• when fed a high-fat diet despite no increase in food intake

liver/biliary system
• when fed a high-fat diet

cellular
• in brown adipocytes





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory