Phenotypes associated with this allele

• Allele Symbol: Clec1b^tm1Lex
• Allele Name: targeted mutation 1, Lexicon Genetics
• Allele ID: MGI:4462254
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Clec1b^tm1Lex/Clec1b^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6J	MGI:4462260

Genotype
MGI:4462260

hm1

• Allelic Composition: Clec1b^tm1Lex/Clec1b^tm1Lex
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:161922 )

• fewer than expected mice are present at weaning

perinatal lethality, incomplete penetrance ( J:161922 )

• most mice are lost perinatally

hematopoietic system

anemia ( J:161922 )

• in the two surviving mice

decreased hematocrit ( J:161922 )

• in the two surviving mice

decreased hemoglobin content ( J:161922 )

• in the two surviving mice

thrombocytopenia ( J:161922 )

• in the two surviving mice

abnormal mononuclear cell morphology ( J:161922 )

• the two surviving mice exhibit an increase in the percentage of CD4+ in peripheral blood mononuclear cells compared with wild-type mice

cardiovascular system

abnormal brain vasculature morphology ( J:161922 )

• at E12.5, mice exhibit dilation of brain capillaries unlike wild-type mice

brain vascular congestion ( J:161922 )

• at E12.5, mice exhibit multifoci of congestion and hemorrhage in the brain and vestibulocochlear ganglion unlike wild-type mice

internal hemorrhage ( J:161922 )

• at E12.5, mice exhibit multifoci of congestion and hemorrhage in the brain and vestibulocochlear ganglion unlike wild-type mice

• at E12.5, mice exhibit bilateral hemorrhage in the neuroepithelium unlike wild-type mice

decreased systemic arterial blood pressure ( J:161922 )

• in the two surviving mice

nervous system

abnormal brain vasculature morphology ( J:161922 )

• at E12.5, mice exhibit dilation of brain capillaries unlike wild-type mice

brain vascular congestion ( J:161922 )

• at E12.5, mice exhibit multifoci of congestion and hemorrhage in the brain and vestibulocochlear ganglion unlike wild-type mice

immune system

abnormal mononuclear cell morphology ( J:161922 )

• the two surviving mice exhibit an increase in the percentage of CD4+ in peripheral blood mononuclear cells compared with wild-type mice