Phenotypes associated with this allele

• Allele Symbol: Pde11a^tm1Dgen
• Allele Name: targeted mutation 1, Deltagen
• Allele ID: MGI:4462264
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pde11a^tm1Dgen/Pde11a^tm1Dgen	involves: 129S/SvEv * C57BL/6	MGI:4462265

Genotype
MGI:4462265

hm1

• Allelic Composition: Pde11a^tm1Dgen/Pde11a^tm1Dgen
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

enhanced behavioral response to xenobiotic ( J:160319 )

• significantly increased hyperlocomotion following injection of glutamate N-methyl-D-aspartate receptor antagonist MK-801

increased locomotor activity ( J:160319 )

• are hyperactive in a novel open field, as indicated by a greater distance traveled over the hour-long session

• significantly increased hyperlocomotion following injection of glutamate N-methyl-D-aspartate receptor antagonist MK-801

abnormal social investigation ( J:160319 )

• male mice display a significant avoidance of an actual stranger male mouse in a social approach/avoidance task

• defects in social odor recognition memory

nervous system

enlarged lateral ventricles ( J:160319 )

• small but significant enlargement of the lateral ventricles