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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Setdb1tm2.2Enl
targeted mutation 2.2, En Li
MGI:4462267
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Setdb1tm2.2Enl/Setdb1tm2.2Enl involves: 129/Sv * C57BL/6 MGI:4462279
cn2
Setdb1tm2.1Enl/Setdb1tm2.2Enl involves: 129/Sv * C57BL/6 MGI:4462280


Genotype
MGI:4462279
hm1
Allelic
Composition
Setdb1tm2.2Enl/Setdb1tm2.2Enl
Genetic
Background
involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Setdb1tm2.2Enl mutation (0 available); any Setdb1 mutation (56 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:4462280
cn2
Allelic
Composition
Setdb1tm2.1Enl/Setdb1tm2.2Enl
Genetic
Background
involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Setdb1tm2.1Enl mutation (0 available); any Setdb1 mutation (56 available)
Setdb1tm2.2Enl mutation (0 available); any Setdb1 mutation (56 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• embryonic stem cells transfected with a cre-ERT2 plasmid and treated with tamoxifen unlike untreated cells flatten and appear differentiated unlike untreated cells
• in embryonic stem cells transfected with a cre-ERT2 plasmid and treated with tamoxifen, expression of pluripotent markers is lost while expression of trophectoderm lineage markers is reduced compared with untreated cells
• in embryonic stem cells transfected with a cre-ERT2 plasmid and treated with tamoxifen, repressive histone H3K9 methylation is lost unlike in untreated cells
• in embryonic stem cells transfected with a cre-ERT2 plasmid and treated with tamoxifen unlike untreated cells





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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory