mortality/aging
• no mice are present at E8.5
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Allele Symbol Allele Name Allele ID |
Setdb1tm2.2Enl targeted mutation 2.2, En Li MGI:4462267 |
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Summary |
2 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• no mice are present at E8.5
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• embryonic stem cells transfected with a cre-ERT2 plasmid and treated with tamoxifen unlike untreated cells flatten and appear differentiated unlike untreated cells
• in embryonic stem cells transfected with a cre-ERT2 plasmid and treated with tamoxifen, expression of pluripotent markers is lost while expression of trophectoderm lineage markers is reduced compared with untreated cells
• in embryonic stem cells transfected with a cre-ERT2 plasmid and treated with tamoxifen, repressive histone H3K9 methylation is lost unlike in untreated cells
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• in embryonic stem cells transfected with a cre-ERT2 plasmid and treated with tamoxifen unlike untreated cells
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/29/2024 MGI 6.24 |
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