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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Cd8a*-cre)B8Asin
transgene insertion B8, Alfred Singer
MGI:4462361
Summary 8 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		B2mtm1Unc/B2mtm1Unc
Il2rgtm1.1Asin/Il2rgtm1Wjl
Tg(Cd8a*-cre)B8Asin/0 		involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 MGI:5469014
cn2
 		B2mtm1Unc/B2mtm1Unc
Il7rtm1.1Asin/Il7rtm1Imx
Tg(Cd8a*-cre)B8Asin/0 		involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 MGI:5469010
cn3
 		Il2rgtm1.1Asin/Il2rgtm1Wjl
Tg(Cd8a*-cre)B8Asin/0 		involves: 129S4/SvJae * C57BL/6 MGI:5469012
cn4
 		Il2rgtm1.1Asin/Il2rgtm1Wjl
Tg(Cd8a*-cre)B8Asin/0
Tg(LCKprBCL2)36Sjk/0 		involves: 129S4/SvJae * C57BL/6 MGI:5469013
cn5
 		Il4ratm1Sz/Il4ratm1Sz
Il7rtm1.1Asin/Il7rtm1Imx
Tg(Cd8a*-cre)B8Asin/0 		involves: 129S7/SvEvBrd * BALB/cJ * C57BL/6 MGI:5469008
cn6
 		Il15tm1Imx/Il15tm1Imx
Il7rtm1.1Asin/Il7rtm1Imx
Tg(Cd8a*-cre)B8Asin/0 		involves: 129S7/SvEvBrd * C57BL/6 MGI:5469009
cn7
 		Il7rtm1.1Asin/Il7rtm1Imx
Tg(Cd8a*-cre)B8Asin/0 		involves: 129S7/SvEvBrd * C57BL/6 MGI:5469007
cn8
 		Taf7tm1.1Dss/Taf7tm1.2Dss
Tg(Cd8a*-cre)B8Asin/0 		involves: C57BL/6 MGI:5430376


Genotype
MGI:5469014
cn1
Allelic
Composition		 B2mtm1Unc/B2mtm1Unc
Il2rgtm1.1Asin/Il2rgtm1Wjl
Tg(Cd8a*-cre)B8Asin/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B2mtm1Unc mutation (38 available); any B2m mutation (122 available)
Il2rgtm1.1Asin mutation (1 available); any Il2rg mutation (179 available)
Il2rgtm1Wjl mutation (83 available); any Il2rg mutation (179 available)
Tg(Cd8a*-cre)B8Asin mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system

hematopoietic system




Genotype
MGI:5469010
cn2
Allelic
Composition		 B2mtm1Unc/B2mtm1Unc
Il7rtm1.1Asin/Il7rtm1Imx
Tg(Cd8a*-cre)B8Asin/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B2mtm1Unc mutation (38 available); any B2m mutation (122 available)
Il7rtm1.1Asin mutation (1 available); any Il7r mutation (31 available)
Il7rtm1Imx mutation (4 available); any Il7r mutation (31 available)
Tg(Cd8a*-cre)B8Asin mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system

hematopoietic system




Genotype
MGI:5469012
cn3
Allelic
Composition		 Il2rgtm1.1Asin/Il2rgtm1Wjl
Tg(Cd8a*-cre)B8Asin/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il2rgtm1.1Asin mutation (1 available); any Il2rg mutation (179 available)
Il2rgtm1Wjl mutation (83 available); any Il2rg mutation (179 available)
Tg(Cd8a*-cre)B8Asin mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased CD8-positive, alpha-beta T cell number ( J:190889 )
• in the thymus but not the periphery due to lymphopenia-induced homeostatic expansion
decreased NK T cell number ( J:190889 )
• of invariant NK T cells in the thymus, spleen and liver
decreased regulatory T cell number ( J:190889 )
• of CD4 single-positive thymocytes expressing Foxp3
• however, these cells are restored by a cross with Tg(LCKprBCL2)36Sjk mice

hematopoietic system
decreased CD8-positive, alpha-beta T cell number ( J:190889 )
• in the thymus but not the periphery due to lymphopenia-induced homeostatic expansion
decreased NK T cell number ( J:190889 )
• of invariant NK T cells in the thymus, spleen and liver
decreased regulatory T cell number ( J:190889 )
• of CD4 single-positive thymocytes expressing Foxp3
• however, these cells are restored by a cross with Tg(LCKprBCL2)36Sjk mice




Genotype
MGI:5469013
cn4
Allelic
Composition		 Il2rgtm1.1Asin/Il2rgtm1Wjl
Tg(Cd8a*-cre)B8Asin/0
Tg(LCKprBCL2)36Sjk/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il2rgtm1.1Asin mutation (1 available); any Il2rg mutation (179 available)
Il2rgtm1Wjl mutation (83 available); any Il2rg mutation (179 available)
Tg(Cd8a*-cre)B8Asin mutation (1 available)
Tg(LCKprBCL2)36Sjk mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased NK T cell number ( J:190889 )
• of invariant NK T cells as in Il2rgtm1.1Asin/Il2rgtm1Wjl Tg(Cd8a*-cre)#Asin mice

hematopoietic system
decreased NK T cell number ( J:190889 )
• of invariant NK T cells as in Il2rgtm1.1Asin/Il2rgtm1Wjl Tg(Cd8a*-cre)#Asin mice




Genotype
MGI:5469008
cn5
Allelic
Composition		 Il4ratm1Sz/Il4ratm1Sz
Il7rtm1.1Asin/Il7rtm1Imx
Tg(Cd8a*-cre)B8Asin/0
Genetic
Background		 involves: 129S7/SvEvBrd * BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il4ratm1Sz mutation (2 available); any Il4ra mutation (46 available)
Il7rtm1.1Asin mutation (1 available); any Il7r mutation (31 available)
Il7rtm1Imx mutation (4 available); any Il7r mutation (31 available)
Tg(Cd8a*-cre)B8Asin mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased CD8-positive, alpha-beta T cell number ( J:190889 )
• in the thymus, as in Il7rtm1.1Asin/Il7rtm1Imx Tg(Cd8a*-cre)#Asin mice

hematopoietic system
decreased CD8-positive, alpha-beta T cell number ( J:190889 )
• in the thymus, as in Il7rtm1.1Asin/Il7rtm1Imx Tg(Cd8a*-cre)#Asin mice




Genotype
MGI:5469009
cn6
Allelic
Composition		 Il15tm1Imx/Il15tm1Imx
Il7rtm1.1Asin/Il7rtm1Imx
Tg(Cd8a*-cre)B8Asin/0
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il15tm1Imx mutation (5 available); any Il15 mutation (44 available)
Il7rtm1.1Asin mutation (1 available); any Il7r mutation (31 available)
Il7rtm1Imx mutation (4 available); any Il7r mutation (31 available)
Tg(Cd8a*-cre)B8Asin mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased CD8-positive, alpha-beta T cell number ( J:190889 )
• in the thymus and periphery, worse than in Il7rtm1.1Asin/Il7rtm1Imx Tg(Cd8a*-cre)#Asin mice

hematopoietic system
decreased CD8-positive, alpha-beta T cell number ( J:190889 )
• in the thymus and periphery, worse than in Il7rtm1.1Asin/Il7rtm1Imx Tg(Cd8a*-cre)#Asin mice




Genotype
MGI:5469007
cn7
Allelic
Composition		 Il7rtm1.1Asin/Il7rtm1Imx
Tg(Cd8a*-cre)B8Asin/0
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il7rtm1.1Asin mutation (1 available); any Il7r mutation (31 available)
Il7rtm1Imx mutation (4 available); any Il7r mutation (31 available)
Tg(Cd8a*-cre)B8Asin mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased CD8-positive, alpha-beta T cell number ( J:190889 )
• in the thymus and periphery

hematopoietic system
decreased CD8-positive, alpha-beta T cell number ( J:190889 )
• in the thymus and periphery




Genotype
MGI:5430376
cn8
Allelic
Composition		 Taf7tm1.1Dss/Taf7tm1.2Dss
Tg(Cd8a*-cre)B8Asin/0
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Taf7tm1.1Dss mutation (0 available); any Taf7 mutation (19 available)
Taf7tm1.2Dss mutation (0 available); any Taf7 mutation (19 available)
Tg(Cd8a*-cre)B8Asin mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased T cell proliferation ( J:185745 )
• after stimulation with either anti-CD3epsilon or a combination of anti-CD3 epsilon and anti-CD28 antibodies in the presence or absence of IL2
abnormal T cell differentiation ( J:185745 )
• modest effect on T cell development
• however, mice exhibit normal differentiation from double positive to single positive thymocyte and differentiation of single positive thymocytes
decreased T cell number ( J:185745 )
• in the lymph nodes
decreased thymocyte number ( J:185745 )
• at the double positive stage

hematopoietic system
decreased T cell proliferation ( J:185745 )
• after stimulation with either anti-CD3epsilon or a combination of anti-CD3 epsilon and anti-CD28 antibodies in the presence or absence of IL2
abnormal T cell differentiation ( J:185745 )
• modest effect on T cell development
• however, mice exhibit normal differentiation from double positive to single positive thymocyte and differentiation of single positive thymocytes
decreased T cell number ( J:185745 )
• in the lymph nodes
decreased thymocyte number ( J:185745 )
• at the double positive stage

endocrine/exocrine glands
decreased thymocyte number ( J:185745 )
• at the double positive stage

cellular
decreased T cell proliferation ( J:185745 )
• after stimulation with either anti-CD3epsilon or a combination of anti-CD3 epsilon and anti-CD28 antibodies in the presence or absence of IL2




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory