Phenotypes associated with this allele

• Allele Symbol: Cacna1c^tm1.1Knt
• Allele Name: targeted mutation 1.1, Jean-Pierre Kinet
• Allele ID: MGI:4462362
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cacna1c^tm1.1Knt/Cacna1c^tm1.1Knt	involves: 129 * C57BL/6J	MGI:4462366

Genotype
MGI:4462366

cn1

• Allelic Composition: Cacna1c^tm1.1Knt/Cacna1c^tm1.1Knt
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:159698 )

N • following injection of cre recombinase into the anterior cingulate cortex, mice exhibit normal behavior in an elevated plus maze, light/dark transition test, open field, novel object recognition, predator exposure, and classical fear conditioning tasks

abnormal learning/memory/conditioning ( J:159698 )

• following injection of cre recombinase into the anterior cingulate cortex, mice exhibit reduced freezing and fecal dropping during observational fear learning compared with PBS-treated mice

• however, classical fear conditioning is normal

increased chemical nociceptive threshold ( J:159698 )

• following injection of cre recombinase into the anterior cingulate cortex, mice exhibit reduced pain behavior in response to formalin or acetic acid compared with PBS-treated mice

• however, mice exhibit normal mechanical and thermal nociception