Phenotypes associated with this allele

• Allele Symbol: Elovl4^tm2Kzh
• Allele Name: targeted mutation 2, Kang Zhang
• Allele ID: MGI:4462372
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Elovl4^tm2Kzh/Elovl4^tm2Kzh	involves: 129X1/SvJ * C57BL/6	MGI:4462377

Genotype
MGI:4462377

hm1

• Allelic Composition: Elovl4^tm2Kzh/Elovl4^tm2Kzh
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality ( J:161118 )

growth/size/body

weight loss ( J:161118 )

• pups removed from their mothers at E19 loose 3% of body weight within 30 minutes

• weight loss of 15% of body weight within 5 hours

homeostasis/metabolism

impaired skin barrier function ( J:161118 )

• E19 homozygotes absorb toluidine blue unlike controls

integument

impaired skin barrier function ( J:161118 )

• E19 homozygotes absorb toluidine blue unlike controls

abnormal epidermis stratum corneum morphology ( J:161118 )

• very thin and fragile

abnormal skin appearance ( J:161118 )

shiny skin ( J:161118 )

• at E19

abnormal skin condition ( J:161118 )

• very long chain fatty acids, with more than 26 carbons are reduced in the skin

• there is a build up of 26 carbon fatty acids

thin skin ( J:161118 )

• at E19

• dermis-epidermis x-section is only 70% of normal thickness