All Phenotypes Magoh<Mos2> MGI Mouse

embryonic growth retardation ( J:240595 )

• at E13.5, heterozygotes show a mild developmental delay relative to wild-type controls

decreased survivor rate ( J:159625 )

• premature death occurs before weaning in some animals

• before weaning with incomplete penetrance

hypopigmentation ( J:159625 )

embryonic growth retardation ( J:240595 )

• at E13.5, heterozygotes show a mild developmental delay relative to wild-type controls

decreased body weight ( J:159625 )

• 33% smaller than control littermates

abnormal neuron apoptosis ( J:159625 )

• most ectopically produced neurons undergo apoptosis

increased brain apoptosis ( J:240595 )

• brains exhibit extensive apoptosis in the cortex at E14.5

abnormal neuron proliferation ( J:159625 )

• ectopic and precocious neurogenesis resulting in expanded calretinin-positive cells and ectopically produced Cajal Retzius cells in cortex

abnormal brain development ( J:159625 )

• at E18.5 the cortical layers were thinner and disorganized

decreased brain size ( J:159625 , J:240595 )

• adult brain weighed significantly less than those of control littermates (J:159625)

• present prenatally starting between E12.5 and E18.5 (J:159625)

• at E18.5, brain size is disproportionally reduced by 30% relative to body size (J:240595)

decreased forebrain size ( J:240595 )

• forebrain size is significantly reduced at E18.5

decreased neocortex size ( J:240595 )

• neocortex size is disproportionally decreased at E13.5

decreased neuron number ( J:159625 )

• intermediate neural progenitors in developing cortex was markedly reduced resulting in the smaller number of neurons in E18.5 brains

ectopic cortical neuron ( J:240595 )

• brains show ectopic neuron differentiation at E12.5

• abnormal orientation of the neural stem cell mitotic division plane during cortex development