All Phenotypes Carmil2<tm1a(KOMP)Mbp> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Carmil2^{tm1a(KOMP)Mbp}
targeted mutation 1a, Mouse Biology Program, UC Davis
MGI:4462559

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Carmil2^bas/Carmil2^{tm1a(KOMP)Mbp}	involves: C3HeB/FeJ * C57BL/6 * C57BL/6N	MGI:5547581

Allelic Composition	Carmil2^bas/Carmil2^{tm1a(KOMP)Mbp}
Genetic Background	involves: C3HeB/FeJ * C57BL/6 * C57BL/6N
Cell Lines	DEPD00524_2_G07

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Carmil2^bas mutation (0 available); any Carmil2 mutation (39 available)
Carmil2^{tm1a(KOMP)Mbp} mutation (1 available); any Carmil2 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased T cell proliferation ( J:205441 )

• T cell proliferation fails to respond in a synergistic way to anti-CD3 and anti-CD28 antibodies unlike wild-type cells

decreased regulatory T cell number ( J:205441 )

• in the thymus and spleen as in Rltpr^Bas homozygotes

decreased interleukin-2 secretion ( J:205441 )

• production from T cell fails to respond in a synergistic way to anti-CD3 and anti-CD28 antibodies unlike wild-type cells

hematopoietic system

decreased T cell proliferation ( J:205441 )

• T cell proliferation fails to respond in a synergistic way to anti-CD3 and anti-CD28 antibodies unlike wild-type cells

decreased regulatory T cell number ( J:205441 )

• in the thymus and spleen as in Rltpr^Bas homozygotes

cellular

decreased T cell proliferation ( J:205441 )

• T cell proliferation fails to respond in a synergistic way to anti-CD3 and anti-CD28 antibodies unlike wild-type cells

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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