Phenotypes associated with this allele

• Allele Symbol: Tnfaip8l3^{tm1a(KOMP)Mbp}
• Allele Name: targeted mutation 1a, Mouse Biology Program, UC Davis
• Allele ID: MGI:4462563
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tnfaip8l3^tm1a(KOMP)Mbp/Tnfaip8l3^tm1a(KOMP)Mbp	C57BL/6N-A^tm1Brd Tnfaip8l3^tm1a(KOMP)Mbp/MbpMmucd	MGI:6385301

Genotype
MGI:6385301

hm1

• Allelic Composition: Tnfaip8l3^{tm1a(KOMP)Mbp}/Tnfaip8l3^{tm1a(KOMP)Mbp}
• Genetic Background: C57BL/6N-A^tm1Brd Tnfaip8l3^{tm1a(KOMP)Mbp}/MbpMmucd
• Cell Lines: DEPD00524_5_A08

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

decreased incidence of tumors by chemical induction ( J:217197 )

• mice subcutaneously injected with the carcinogen 3-methyl-cholanthrene show delayed skin tumor onset and reduced tumor size compared to wild-type mice

• fibrosarcoma cells from tumor-induced mice grow much slower in culture

• however, mice develop normally and do not exhibit signs of spontaneous diseases during the first 3 months of life

decreased tumor latency ( J:217197 )

• mice subcutaneously injected with the carcinogen 3-methyl-cholanthrene show delayed skin tumor onset

homeostasis/metabolism

decreased incidence of tumors by chemical induction ( J:217197 )

• mice subcutaneously injected with the carcinogen 3-methyl-cholanthrene show delayed skin tumor onset and reduced tumor size compared to wild-type mice

• fibrosarcoma cells from tumor-induced mice grow much slower in culture

• however, mice develop normally and do not exhibit signs of spontaneous diseases during the first 3 months of life