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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Glultm3Whla
targeted mutation 3, Wouter H Lamers
MGI:4462791
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Glultm3Whla/Glultm1Whla
Tg(Ckmm-cre)5Khn/0 		involves: 129P2/OlaHsd * FVB MGI:4462798
cn2
 		Glultm3Whla/Glultm3Whla
Tg(Ckmm-cre)5Khn/0 		involves: 129P2/OlaHsd * FVB MGI:4462799
cn3
 		Glultm3Whla/Glultm1Whla
Tg(GFAP-cre)25Mes/0 		involves: 129P2/OlaHsd * FVB/N MGI:4462796
cn4
 		Glultm3Whla/Glultm3Whla
Tg(GFAP-cre)25Mes/0 		involves: 129P2/OlaHsd * FVB/N MGI:4462797


Genotype
MGI:4462798
cn1
Allelic
Composition		 Glultm3Whla/Glultm1Whla
Tg(Ckmm-cre)5Khn/0
Genetic
Background		 involves: 129P2/OlaHsd * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Glultm1Whla mutation (0 available); any Glul mutation (35 available)
Glultm3Whla mutation (1 available); any Glul mutation (35 available)
Tg(Ckmm-cre)5Khn mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal amino acid level ( J:161082 )
• 35% increase in branched-chain amino acids
decreased glutamine level ( J:161082 )
• muscle glutamine 20-30% lower
decreased circulating glutamine level ( J:161082 )
• 20% reduction in plasma glutamine in starved mice
abnormal ammonia homeostasis ( J:161082 )
• detoxification of ammonia is two fold lower

growth/size/body
abnormal postnatal growth ( J:161082 )
• faster weight loss when fasting but only for the first 20 hours




Genotype
MGI:4462799
cn2
Allelic
Composition		 Glultm3Whla/Glultm3Whla
Tg(Ckmm-cre)5Khn/0
Genetic
Background		 involves: 129P2/OlaHsd * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Glultm3Whla mutation (1 available); any Glul mutation (35 available)
Tg(Ckmm-cre)5Khn mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
abnormal postnatal growth ( J:161082 )
• faster weight loss when fasting but only for the first 20 hours

homeostasis/metabolism
abnormal amino acid level ( J:161082 )
• 20% reduction in plasma glutamine in starved mice
• muscle glutamine20-30% lower
• 35% increase in branched-chain amino acids
abnormal ion homeostasis ( J:161082 )
• detoxification of ammonia is two fold lower




Genotype
MGI:4462796
cn3
Allelic
Composition		 Glultm3Whla/Glultm1Whla
Tg(GFAP-cre)25Mes/0
Genetic
Background		 involves: 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Glultm1Whla mutation (0 available); any Glul mutation (35 available)
Glultm3Whla mutation (1 available); any Glul mutation (35 available)
Tg(GFAP-cre)25Mes mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:162067 )
• born in normal numbers
• none found at 6-8 days of age
• death at 2-3 days of age

behavior/neurological
abnormal food intake ( J:162067 )
• nursed immediately after birth but milk intake then declined

nervous system
abnormal brain morphology ( J:162067 )
• moderately elevated brain ammonia levels
• no gross brain malformations

homeostasis/metabolism
decreased alanine level ( J:162067 )
• decreased alanine in the cortex of the brain at two days of age
decreased glutamine level ( J:162067 )
• decreased glutamine in the cortex of the brain at two days of age
increased glycine level ( J:162067 )
• increased glycine in the cortex of the brain at two days of age
abnormal ammonia homeostasis ( J:162067 )
• moderately elevated brain ammonia levels
decreased circulating glucose level ( J:162067 )
• blood glucose levels at 30% of controls at 2 days of age




Genotype
MGI:4462797
cn4
Allelic
Composition		 Glultm3Whla/Glultm3Whla
Tg(GFAP-cre)25Mes/0
Genetic
Background		 involves: 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Glultm3Whla mutation (1 available); any Glul mutation (35 available)
Tg(GFAP-cre)25Mes mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:162067 )
• born in normal numbers
• none found at 6-8 days of age
• death at 2-3 days of age

behavior/neurological
abnormal food intake ( J:162067 )
• nursed immediately after birth but milk intake then declined

homeostasis/metabolism
decreased alanine level ( J:162067 )
• decreased alanine in the cortex of the brain at two days of age
decreased glutamine level ( J:162067 )
• decreased glutamine in the cortex of the brain at two days of age
increased glycine level ( J:162067 )
• increased glycine in the cortex of the brain at two days of age
abnormal ammonia homeostasis ( J:162067 )
• moderately elevated brain ammonia levels
decreased circulating glucose level ( J:162067 )
• blood glucose levels at 30% of controls at 2 days of age

nervous system
abnormal brain morphology ( J:162067 )
• moderately elevated brain ammonia levels
• no gross brain malformations




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory