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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Ins1-SLC2A1)1Thor
transgene insertion 1, Bernard Thorens
MGI:4462831
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Slc2a2tm1Thor/Slc2a2tm1Thor
Tg(Ins1-SLC2A1)1Thor/0
involves: 129P2/OlaHsd * C57BL/6 MGI:4818917
cx2
Slc2a2tm1Thor/Slc2a2+
Tg(Ins1-SLC2A1)1Thor/0
involves: 129P2/OlaHsd * C57BL/6 MGI:4818918


Genotype
MGI:4818917
cx1
Allelic
Composition
Slc2a2tm1Thor/Slc2a2tm1Thor
Tg(Ins1-SLC2A1)1Thor/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc2a2tm1Thor mutation (0 available); any Slc2a2 mutation (32 available)
Tg(Ins1-SLC2A1)1Thor mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• expression of transgene prevents early lethality observed in Slc2a2tm1Thor homozygous non-transgenic mice

growth/size/body
N
• body weight and composition are identical to wild-type controls at 12-16 weeks

homeostasis/metabolism
• during 24 h of food deprivation, body temperature decreases significantly compared to wild-type controls at end of dark period as mice enter torpor
• when exposed continuously to low temperature (4 degrees C), mutants show reduced ability to regulate and maintain body temperature compared to controls
• when mice are deprived of food for 6 h and receive intracerebroventricular injections of 2-deoxyglucose (0.5 mg, 1.5 mg or 2.5 mg), no significant decrease in body temperature is observed compared to wild-type controls at the lowest dose after 2 hours; at the median dose, a significant difference is seen at 2 hours but is less significant than controls; at the highest dose, temperature decrease is similar to that observed in controls

behavior/neurological
• at end of dark period, mutants show less locomotor acitivity compared to controls as they enter torpor during 24 h of food deprivation
• when exposed continuously to low temperature (4 degrees C), mutants and wild-type controls display similar locomotor activity




Genotype
MGI:4818918
cx2
Allelic
Composition
Slc2a2tm1Thor/Slc2a2+
Tg(Ins1-SLC2A1)1Thor/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc2a2tm1Thor mutation (0 available); any Slc2a2 mutation (32 available)
Tg(Ins1-SLC2A1)1Thor mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
N
• body weight and composition are identical to controls at 12-16 weeks

homeostasis/metabolism
N
• during 24 h of food deprivation, body temperature is similar to wild-type controls and does not drop as significantly as Slc2a2 homozygous transgenics
• responses to intracerebroventricular injections of 2-deoxyglucose (0.5 mg, 1.5 mg or 2.5 mg) are similar to controls

behavior/neurological
N
• during 24 h of food deprivation, locomotor activity remains similar to wild-type controls





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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory