mortality/aging
N |
• expression of transgene prevents early lethality observed in Slc2a2tm1Thor homozygous non-transgenic mice
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growth/size/body
N |
• body weight and composition are identical to wild-type controls at 12-16 weeks
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homeostasis/metabolism
• during 24 h of food deprivation, body temperature decreases significantly compared to wild-type controls at end of dark period as mice enter torpor
• when exposed continuously to low temperature (4 degrees C), mutants show reduced ability to regulate and maintain body temperature compared to controls
• when mice are deprived of food for 6 h and receive intracerebroventricular injections of 2-deoxyglucose (0.5 mg, 1.5 mg or 2.5 mg), no significant decrease in body temperature is observed compared to wild-type controls at the lowest dose after 2 hours; at the median dose, a significant difference is seen at 2 hours but is less significant than controls; at the highest dose, temperature decrease is similar to that observed in controls
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behavior/neurological
• at end of dark period, mutants show less locomotor acitivity compared to controls as they enter torpor during 24 h of food deprivation
• when exposed continuously to low temperature (4 degrees C), mutants and wild-type controls display similar locomotor activity
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