homeostasis/metabolism
• fed mice exhibit reduced exercise capacity compared with control Gys2tm1.1Pro homozygotes
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• during a fast, mice exhibit a more acute increase in ketone bodies than in similarly treated control Gys2tm1.1Pro homozygotes
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• in fed and fasted states, mice exhibit reduced circulating glucose levels compared with similarly treated control Gys2tm1.1Pro homozygotes
• mice enter a fasted state quicker than similarly treated control Gys2tm1.1Pro homozygotes
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• under fed condition
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• mice exhibit enhanced gluconeogenesis compared with control Gys2tm1.1Pro homozygotes
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• glycogen liver content is reduced 94% compared to in control Gys2tm1.1Pro homozygotes
• exercised mice exhibit a greater decrease in muscle glycogen levels compared with control Gys2tm1.1Pro homozygotes
• however, glycogen content in the skeletal muscle and kidney is normal
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• fasting mice fail to exhibit a change in triglyceride levels unlike fasted control Gys2tm1.1Pro homozygotes
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• at 7 and 15 months
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cardiovascular system
• heart glucose uptake is lower than in control Gys2tm1.1Pro homozygotes
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liver/biliary system
• at 7 and 15 months
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muscle
• heart glucose uptake is lower than in control Gys2tm1.1Pro homozygotes
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behavior/neurological
• fed mice exhibit reduced exercise capacity compared with control Gys2tm1.1Pro homozygotes
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cellular
• heart glucose uptake is lower than in control Gys2tm1.1Pro homozygotes
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