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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ssbp2tm1Lana
targeted mutation 1, Lalitha Nagarajan
MGI:4462848
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ssbp2tm1Lana/Ssbp2tm1Lana involves: 129S/SvEv * C57BL/6 MGI:4462850
cx2
 		Ssbp2tm1Lana/Ssbp2tm1Lana
Trp53tm1Tyj/Trp53tm1Tyj 		involves: 129S/SvEv * 129S2/SvPas * BALB/c * C57BL/6 MGI:4462851


Genotype
MGI:4462850
hm1
Allelic
Composition		 Ssbp2tm1Lana/Ssbp2tm1Lana
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ssbp2tm1Lana mutation (0 available); any Ssbp2 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:162035 )
• 50% of mice die by 68 weeks of age unlike wild-type mice
perinatal lethality, incomplete penetrance ( J:162035 )
• slightly fewer than expected live births are observed

neoplasm
increased adenoma incidence ( J:162035 )
• in the lung of one morbid mouse
increased lung adenoma incidence ( J:162035 )
• in 1 of 12 non-morbid mice
increased lymphoma incidence ( J:162035 )
• in 6 of 13 morbid mice
• in 4 of 12 non-morbid mice
increased malignant tumor incidence ( J:162035 )
• 62% of moribund and 50% non-moribund mice develop full-blown malignancies between 60 and 80 weeks unlike wild-type mice
increased carcinoma incidence ( J:162035 )
• in 2 of 13 morbid mice (Hardian gland and lung)
increased jejunum adenocarcinoma incidence ( J:162035 )
• in 1 of 12 non-morbid mice
increased squamous cell carcinoma incidence ( J:162035 )
• in 1 of 12 non-morbid mice
increased sarcoma incidence ( J:162035 )
• in 1 of 12 non-morbid mice

immune system
arteritis ( J:162035 )
• some mice exhibit polyarteritis unlike wild-type mice
increased pre-B cell number ( J:162035 )
• in the bone marrow at 6 weeks of age
decreased lymphocyte cell number ( J:162035 )
• in some mice with lymphomas

cardiovascular system
arteritis ( J:162035 )
• some mice exhibit polyarteritis unlike wild-type mice

renal/urinary system
abnormal kidney morphology ( J:162035 )
• some mice exhibit glomerular nephropathy unlike wild-type mice

skeleton
abnormal joint morphology ( J:162035 )
• some mice exhibit degenerative joint disease unlike wild-type mice

hematopoietic system
anemia ( J:162035 )
• in some mice
increased pre-B cell number ( J:162035 )
• in the bone marrow at 6 weeks of age
decreased lymphocyte cell number ( J:162035 )
• in some mice with lymphomas
pancytopenia ( J:162035 )
• in some mice with lymphomas

respiratory system
increased lung adenoma incidence ( J:162035 )
• in 1 of 12 non-morbid mice

digestive/alimentary system
increased jejunum adenocarcinoma incidence ( J:162035 )
• in 1 of 12 non-morbid mice




Genotype
MGI:4462851
cx2
Allelic
Composition		 Ssbp2tm1Lana/Ssbp2tm1Lana
Trp53tm1Tyj/Trp53tm1Tyj
Genetic
Background		 involves: 129S/SvEv * 129S2/SvPas * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ssbp2tm1Lana mutation (0 available); any Ssbp2 mutation (38 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:162035 )
• median survival is 122 days instead of 182 days for Trp53tm1Tyj homozygotes

neoplasm
increased T cell derived lymphoma incidence ( J:162035 )
• mice exhibit a 2.4-fold increase in thymic lymphomas compared with Trp53tm1Tyj homozygotes
• thymic lymphomas are more aggressive than in Trp53tm1Tyj homozygotes

immune system
thymus hypoplasia ( J:162035 )
• at 3 and 6 months
increased T cell derived lymphoma incidence ( J:162035 )
• mice exhibit a 2.4-fold increase in thymic lymphomas compared with Trp53tm1Tyj homozygotes
• thymic lymphomas are more aggressive than in Trp53tm1Tyj homozygotes

hematopoietic system
thymus hypoplasia ( J:162035 )
• at 3 and 6 months
increased T cell derived lymphoma incidence ( J:162035 )
• mice exhibit a 2.4-fold increase in thymic lymphomas compared with Trp53tm1Tyj homozygotes
• thymic lymphomas are more aggressive than in Trp53tm1Tyj homozygotes

endocrine/exocrine glands
thymus hypoplasia ( J:162035 )
• at 3 and 6 months
increased T cell derived lymphoma incidence ( J:162035 )
• mice exhibit a 2.4-fold increase in thymic lymphomas compared with Trp53tm1Tyj homozygotes
• thymic lymphomas are more aggressive than in Trp53tm1Tyj homozygotes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory