Analysis Tools|
Allele Symbol Allele Name Allele ID |
Grb2tm1.1Hua targeted mutation 1.1, Hua Gu MGI:4462852 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• positive selection of CD4+ cells is severely impaired compared to in DO11.10 TCR control mice
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• positive selection of CD4+ cells is severely impaired compared to in DO11.10 TCR control mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• slightly in the thymus and lymph nodes
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• maturation of double positive thymocytes to single positive thymocytes is impaired compared to in wild-type mice
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• mice exhibit a marked decrease in CD4+ T cells in the thymus compared with wild-type mice
• peripheral CD4+ T cells in the spleen and lymph node are decreased compared to in wild-type mice
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• mice exhibit a moderate decrease in CD8+ T cells in the thymus compared with wild-type mice
• peripheral CD8+ T cells in the spleen and lymph node are decreased compared to in wild-type mice
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• slightly in the thymus and lymph nodes
|
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• maturation of double positive thymocytes to single positive thymocytes is impaired compared to in wild-type mice
|
|
• mice exhibit a marked decrease in CD4+ T cells in the thymus compared with wild-type mice
• peripheral CD4+ T cells in the spleen and lymph node are decreased compared to in wild-type mice
|
|
• mice exhibit a moderate decrease in CD8+ T cells in the thymus compared with wild-type mice
• peripheral CD8+ T cells in the spleen and lymph node are decreased compared to in wild-type mice
|
|
• slightly in the thymus and lymph nodes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• positive selection of CD8+ cells in female mice is impaired compared to in H-Y TCR control mice
• male mice fail to exhibit negative selection of double positive and CD8+ T cells unlike H-Y TCR control mice
• Staphylococcal enterotoxin B (SEB)-treated mice fail to exhibit a decrease in TCR Vbeta8+ thymocytes unlike similarly treated H-Y TCR control mice
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• in male mice
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• in male mice
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• in female mice
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• in male mice
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• positive selection of CD8+ cells in female mice is impaired compared to in H-Y TCR control mice
• male mice fail to exhibit negative selection of double positive and CD8+ T cells unlike H-Y TCR control mice
• Staphylococcal enterotoxin B (SEB)-treated mice fail to exhibit a decrease in TCR Vbeta8+ thymocytes unlike similarly treated H-Y TCR control mice
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• in male mice
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• in male mice
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• in female mice
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• in male mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/19/2024 MGI 6.24 |
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