Analysis Tools|
Allele Symbol Allele Name Allele ID |
Fgf22tm1Dgen targeted mutation 1, Deltagen MGI:4818348 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• pentylenetetrazol-treated mice fail to exhibit seizures at doses that elicit seizures in wild-type mice
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• pentylenetetrazol-treated mice fail to exhibit seizures at doses that elicit seizures in wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at asymmetric synapses, synaptic vesicles are more diffusely distributed and smaller than in wild-type mice
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• fewer vesicles are docked at asymmetric synapses compared to in wild-type mice
• however, the number of docked vesicles at symmetric synapses is normal
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• at P14, vesicle clustering in glutamatergic synapses is decreased in the CA3 compared to in wild-type mice
• CA3 pyramidal neurons cultured for 14 days have fewer glutamatergic vesicles associated with dendrites compared to in cultured wild-type neurons
• however, vesicle clustering in GABAergic synapses is normal
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• the frequency of miniature excitatory postsynaptic currents (mEPSCs) is decreased compared to in wild-type hippocampal cultures
• however, the amplitude of mEPSCs is normal
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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