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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gja5tm1Mchn
targeted mutation 1, Marc Chanson
MGI:4818408
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gja5tm1Mchn/Gja5tm1Mchn involves: BALB/c * C57BL/6 MGI:4818409
cn2
 		Apoetm1Unc/Apoetm1Unc
Gja5tm1Mchn/Gja5tm1Mchn
Tg(TIE2-lacZ)182Sato/0 		involves: 129P2/OlaHsd * BALB/c * C57BL/6 MGI:4818410
cn3
 		Gja5tm1Mchn/Gja5tm1Mchn
Tg(Tek-cre/ERT2)1Arnd/0 		involves: C57BL/6 * DBA/2 MGI:4818413


Genotype
MGI:4818409
hm1
Allelic
Composition		 Gja5tm1Mchn/Gja5tm1Mchn
Genetic
Background		 involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gja5tm1Mchn mutation (1 available); any Gja5 mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:162224 )
• mice are indistinguishable from wild-type mice




Genotype
MGI:4818410
cn2
Allelic
Composition		 Apoetm1Unc/Apoetm1Unc
Gja5tm1Mchn/Gja5tm1Mchn
Tg(TIE2-lacZ)182Sato/0
Genetic
Background		 involves: 129P2/OlaHsd * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation (33 available); any Apoe mutation (158 available)
Gja5tm1Mchn mutation (1 available); any Gja5 mutation (19 available)
Tg(TIE2-lacZ)182Sato mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:162224 )
N
• mice exhibit normal mean arterial pressure, heart rate, and endothelium-dependent vasomotor responses to KCl and norepinephrine
increased susceptibility to atherosclerosis ( J:162224 )
• whether fed a high-fat or standard diet, mice exhibit increased lipid staining in the thoracoabdominal aortas compared with Apoetm1Unc homozygotes
• whether fed a high-fat or standard diet, mice exhibit accelerated atherosclerosis compared with Apoetm1Unc homozygotes

immune system
abnormal neutrophil physiology ( J:162224 )
• LPS-treated mice exhibit increased inflammatory cell recruitment, mostly neutrophils, into the alveolar spaces compared with similarly treated Apoetm1Unc homozygotes
alveolitis ( J:162224 )
• LPS-treated mice exhibit increased inflammatory cell recruitment, mostly neutrophils, into the alveolar spaces compared with similarly treated Apoetm1Unc homozygotes

respiratory system
alveolitis ( J:162224 )
• LPS-treated mice exhibit increased inflammatory cell recruitment, mostly neutrophils, into the alveolar spaces compared with similarly treated Apoetm1Unc homozygotes

hematopoietic system
abnormal neutrophil physiology ( J:162224 )
• LPS-treated mice exhibit increased inflammatory cell recruitment, mostly neutrophils, into the alveolar spaces compared with similarly treated Apoetm1Unc homozygotes




Genotype
MGI:4818413
cn3
Allelic
Composition		 Gja5tm1Mchn/Gja5tm1Mchn
Tg(Tek-cre/ERT2)1Arnd/0
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gja5tm1Mchn mutation (1 available); any Gja5 mutation (19 available)
Tg(Tek-cre/ERT2)1Arnd mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased susceptibility to injury ( J:161949 )
• tamoxifen treated mice subjected to femoral artery occlusion exhibit reduced hindlimb perfusion compared with similarly treated wild-type mice




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory