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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hbegftm4Mek
targeted mutation 4, Eisuke Mekada
MGI:4818437
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Hbegftm4Mek/Hbegftm4Mek B6.Cg-Hbegftm4Mek MGI:4818454
ht2
 		Hbegftm4Mek/Hbegf+ B6.Cg-Hbegftm4Mek MGI:4818455


Genotype
MGI:4818454
hm1
Allelic
Composition		 Hbegftm4Mek/Hbegftm4Mek
Genetic
Background		 B6.Cg-Hbegftm4Mek
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hbegftm4Mek mutation (0 available); any Hbegf mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:161948 )
N
• unlike in mice homozygous for other alleles of this gene, heart chamber formation is normal
abnormal atrioventricular valve morphology ( J:161948 )
• atrioventricular valve thickness is increased due to an increase in mesenchyme compared to in wild-type mice
abnormal heart ventricle outflow tract morphology ( J:161948 )
• outflow tract valve thickness is increased due to an increase in mesenchyme compared to in wild-type mice
abnormal cardiovascular system physiology ( J:161948 )
• in vivo proliferation of outflow tract (OFT) and atrioventricular (AV) valve mesenchyme and endocardial cells is increased compared to in wild-type mice
• proliferation of mesenchyme and endocardial cells from cushion explants in culture is increased compared to wild-type explants
• however, apoptosis of mesenchyme cells from outflow tract valves is normal

respiratory system
respiratory system phenotype ( J:161948 )
N
• unlike in mice homozygous for other alleles of this gene, lung development is normal




Genotype
MGI:4818455
ht2
Allelic
Composition		 Hbegftm4Mek/Hbegf+
Genetic
Background		 B6.Cg-Hbegftm4Mek
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hbegftm4Mek mutation (0 available); any Hbegf mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal cardiovascular system physiology ( J:161948 )
• proliferation of mesenchyme and endocardial cells from cushion explants in culture is increased compared to wild-type explants




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory