Analysis Tools|
Allele Symbol Allele Name Allele ID |
Slc6a9tm1Veul targeted mutation 1, Volker Eulenburg MGI:4818447 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• no hypotonia
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| N |
• no motor defects seen in open field or rotarod tests
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• GlyT1 specific uptake of glycine by hippocampal membranes is reduced 50%
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• die within 8 hours of birth
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• hypotonic phenotype leads to premature death
• frequency of deaths peaks at around 3 days of age
• 20% of mice have a normal life span
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• 80% of homozygotes show a strong hypotonic phenotype
• onset from day 1 through 10 days of age
• 20% of mice develop no phenotype
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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