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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(APOE-SGMS2)#Jia
transgene insertion, Xian-Cheng Jiang
MGI:4818467
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(APOE-SGMS2)#Jia/0 involves: C57BL/6 * C57BL/6J * CBA MGI:4818470


Genotype
MGI:4818470
tg1
Allelic
Composition
Tg(APOE-SGMS2)#Jia/0
Genetic
Background
involves: C57BL/6 * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• whether mice are fed a high-fat diet or chow, plasma ApoE levels are decreased compared to in wild-type mice
• liver sphingomyelin (SM) levels are increased compared to in wild-type mice
• sphingosine-1-phosphate levels in the liver are increased compared to in wild-type mice
• liver ceramide levels are decreased compared to in wild-type mice
• mice fed a high cholesterol diet exhibit an increase in plasma SM (HDL and non-HDL) levels compared with similarly treated wild-type mice

liver/biliary system
• hepatocytes are more sensitive to lysenin-mediated cytolysis than wild-type cells





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory