homeostasis/metabolism
• whether mice are fed a high-fat diet or chow, plasma ApoE levels are decreased compared to in wild-type mice
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• liver sphingomyelin (SM) levels are increased compared to in wild-type mice
• sphingosine-1-phosphate levels in the liver are increased compared to in wild-type mice
• liver ceramide levels are decreased compared to in wild-type mice
• mice fed a high cholesterol diet exhibit an increase in plasma SM (HDL and non-HDL) levels compared with similarly treated wild-type mice
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liver/biliary system
• hepatocytes are more sensitive to lysenin-mediated cytolysis than wild-type cells
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