Phenotypes associated with this allele

• Allele Symbol: Ttyh1^tm1Tohe
• Allele Name: targeted mutation 1, Toshio Heike
• Allele ID: MGI:4818475
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ttyh1^tm1Tohe/Ttyh1^tm1Tohe	involves: C57BL/6 * C57BL/6J * CBA	MGI:4818476

Genotype
MGI:4818476

hm1

• Allelic Composition: Ttyh1^tm1Tohe/Ttyh1^tm1Tohe
• Genetic Background: involves: C57BL/6 * C57BL/6J * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality before implantation, complete penetrance ( J:161796 )

• live embryos are present at E3.5 but none are found at E6.5

• cultured embryos arrest before the blastocyst stage

embryo

embryonic growth arrest ( J:161796 )

• arrest before the blastocyst stage

cellular

abnormal cell nucleus morphology ( J:161796 )

• cultured E3.5 embryos display multiple, small and irregular nuclei formation

increased cell nucleus count ( J:161796 )

abnormal mitosis ( J:161796 )

• cultured E3.5 embryos undergo mitotic failure